日药厂采免疫桥接认证新冠疫苗 by cloudblade

View this thread on: hive.blog | peakd.com | ecency.com

cn · @cloudblade · Jul 18 '21

$0.13

日药厂采免疫桥接认证新冠疫苗

https://steemitimages.com/640x380/https://cdn.steemitimages.com/DQmcryN5Xy958oopHjUAYvApQpZtA3JVR9arh4rs9TGZQuJ/image.png

日药厂采免疫桥接认证新冠疫苗

日本知名国价大药厂第一三共近日宣布，将以免疫桥接方式来替代三期临床试验。

日本可能是第一个采用免疫桥接方式来作为COVID-19疫苗紧急使用授权（EUA）标准的国家。

COVID-19病毒于去年爆发，全球疫情严峻，是COVID-19疫苗三期临床试验的黄金时期，但随越各种疫苗的施打，疫苗施打涵盖率的提升，要寻找适合COVID-19疫苗三期临床试验的区域并不容易，使用传统临床试验来检验新一代疫苗的效果将越来越不可行，免疫桥接势必成为疫苗三期试验的替代方案。

世界卫生组织（WHO）便于5 月底与各国开会讨论过，以免疫桥接来评估疫苗的效果。

之所以期望使用免疫桥接，有三大因素，其一是国际间之疫苗施打已有了一定的覆盖率，要寻找疫苗覆盖率低的地区和征招数万名志愿者来进行大规模的临床试验有其难度；其二，以传统临床试验让对照组受试者施打安慰剂，恐危害其安全；第三则是不公平。

当时的WHO会议仅为凝聚共识，直到近期，全球药政主管单位共组的国际药物法规主管机关联盟（ICMRA）召开研讨会，首度达成共识，若传统三期临床试验不可行，可以免疫桥接进行「非劣性试验」，以评估疫苗有效性。

故而，日本第一三共药厂宣布以此方式作为日本国产mRNA疫苗的临床试验。

👍 ctime, prechyrukky, moeenali, lizanomadsoul, sonu084, allics, hivebuzz, kgsupport, canna-collective, freemonster, spinvest-leo, oleg326756, manncpt, brutalmonkey, brulass, kirazay, guurry123, frassman, toni.ggame, mutiahanum, holovision.cash

`author`	cloudblade
`permlink`	71wcoy
`category`	cn
`json_metadata`	{"tags":["cn","lassecash","palnet","telokanda","archon","broadhive","proofofbrain","lern"],"image":["https://steemitimages.com/640x380/https://cdn.steemitimages.com/DQmcryN5Xy958oopHjUAYvApQpZtA3JVR9arh4rs9TGZQuJ/image.png"],"app":"hiveblog/0.1","format":"markdown"}
`created`	2021-07-18 03:35:03
`last_update`	2021-07-18 03:35:03
`depth`	0
`children`	3
`last_payout`	2021-07-25 03:35:03
`cashout_time`	1969-12-31 23:59:59
`total_payout_value`	0.064 HBD
`curator_payout_value`	0.062 HBD
`pending_payout_value`	0.000 HBD
`promoted`	0.000 HBD
`body_length`	667
`author_reputation`	26,961,334,885,138
`root_title`	日药厂采免疫桥接认证新冠疫苗
`beneficiaries`	`[]`
`max_accepted_payout`	1,000,000.000 HBD
`percent_hbd`	10,000
`post_id`	104,984,452
`net_rshares`	278,037,144,590
`author_curate_reward`	""

properties (23)vote details (21)

voter	rshares	pct
oleg326756	823,103,108	10%
lizanomadsoul	2,378,149,148	1%
sonu084	1,744,168,079	100%
kirazay	661,028,641	100%
manncpt	776,885,698	1%
moeenali	6,467,769,546	1%
mutiahanum	141,149,255	100%
frassman	338,932,789	18%
prechyrukky	7,150,474,062	100%
guurry123	392,886,177	2%
canna-collective	1,580,244,406	5%
ctime	246,294,960,434	2.5%
allics	1,734,389,707	100%
freemonster	1,453,317,455	100%
spinvest-leo	1,178,553,038	4%
toni.ggame	146,932,186	1.75%
kgsupport	1,619,925,601	36%
hivebuzz	1,702,760,602	1%
brulass	699,458,491	100%
brutalmonkey	752,056,167	100%
holovision.cash	0	50%

@eii · Jul 18 '21

!PIZZA
!BEER

properties (22)

`author`	eii
`permlink`	re-cloudblade-qwfsid
`category`	cn
`json_metadata`	{"tags":["cn"],"app":"peakd/2021.07.2"}
`created`	2021-07-18 10:44:39
`last_update`	2021-07-18 10:44:39
`depth`	1
`children`	1
`last_payout`	2021-07-25 10:44:39
`cashout_time`	1969-12-31 23:59:59
`total_payout_value`	0.000 HBD
`curator_payout_value`	0.000 HBD
`pending_payout_value`	0.000 HBD
`promoted`	0.000 HBD
`body_length`	12
`author_reputation`	152,971,745,564,514
`root_title`	日药厂采免疫桥接认证新冠疫苗
`beneficiaries`	`[]`
`max_accepted_payout`	1,000,000.000 HBD
`percent_hbd`	10,000
`post_id`	104,988,873
`net_rshares`	0

@pizzabot · Jul 18 '21

<div class='pull-right'><center><sup>Connect</sup></center><p><a href="https://discord.gg/Q9bQAKpWGS"><img src="https://files.peakd.com/file/peakd-hive/pizzabot/AKF96fKjnX3wjXERHcKAFHaoHnfTVhXqPjXVz8E1Th9nPiJqmFtaycosVpPBZ7z.png"></a></p></div><div class='pull-right'><center><sup>Trade</sup></center><p><a href='https://hive-engine.com/?p=market&t=PIZZA'><img src="https://files.peakd.com/file/peakd-hive/pizzabot/23sxbi2M4UjELDzQjxPdzubdgfMjHTCtA1xueyxmnhJUrB8136VyK3pqynyWYiZYF9HrC.png"></a></p></div><center><br> <p>@cloudblade! I sent you a slice of <strong><em>$PIZZA</em></strong> on behalf of @eii.</p> <p>Learn more about <strong><em>$PIZZA Token</em></strong> at <a href="https://hive.pizza">hive.pizza</a> <sub>(8/10)</sub></p> </center><div></div>

properties (22)

`author`	pizzabot
`permlink`	re-re-cloudblade-qwfsid-20210718t104539z
`category`	cn
`json_metadata`	"{"app": "beem/0.24.26"}"
`created`	2021-07-18 10:45:39
`last_update`	2021-07-18 10:45:39
`depth`	2
`children`	0
`last_payout`	2021-07-25 10:45:39
`cashout_time`	1969-12-31 23:59:59
`total_payout_value`	0.000 HBD
`curator_payout_value`	0.000 HBD
`pending_payout_value`	0.000 HBD
`promoted`	0.000 HBD
`body_length`	759
`author_reputation`	6,152,395,739,296
`root_title`	日药厂采免疫桥接认证新冠疫苗
`beneficiaries`	`[]`
`max_accepted_payout`	1,000,000.000 HBD
`percent_hbd`	10,000
`post_id`	104,988,881
`net_rshares`	0

@hivebuzz · Jul 19 '21

Congratulations @cloudblade! You have completed the following achievement on the Hive blockchain and have been rewarded with new badge(s) :

<table><tr><td><img src="https://images.hive.blog/60x60/http://hivebuzz.me/badges/postallweek.png"></td><td>You have been a buzzy bee and published a post every day of the week</td></tr>
</table>

<sub>_You can view your badges on [your board](https://hivebuzz.me/@cloudblade) and compare yourself to others in the [Ranking](https://hivebuzz.me/ranking)_</sub>
<sub>_If you no longer want to receive notifications, reply to this comment with the word_ `STOP`</sub>


To support your work, I also upvoted your post!

properties (22)