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| parent_permlink | hive-196387 |
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| author | lupafilotaxia |
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| permlink | fitofarmacologia-propiedades-fitofarmacologicas-de-especimenes-de-capsicum-annum-aji-dulce |
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| title | "FITOFARMACOLOGÍA // Propiedades fitofarmacológicas de especímenes de Capsicum annum (Ají dulce)" |
|---|
| body | "<html>
<center><img src="https://i.imgur.com/irC6KpT.png"/></center>
<hr />
<p></p>
<div class="text-justify">Hablar de la diversidad vegetal, es referirse a la multiplicidad bilógica que la naturaleza dispone para garantizar la vida, dónde cada espécimen tiene codificado sustancias fitoquímicas de cierta especificidad fitofarmacológica, que a lo largo del tiempo hemos usados los seres humanos para gozar de una vida sana y libre de enfermedades, es por ello, y en la búsqueda de continuar desarrollando contenido de corte fitofarmacológico, el objetivo del presente manuscrito consiste en presentar contenido experimental y clínico relacionado a las <strong>propiedades fitofarmacológicas de especímenes de <em>Capsicum annum</em> (Ají dulce).</strong></div>
<p></p>
<hr />
<center><h1>Introducción</h1></center>
<hr />
<p></p>
<div class="text-justify">La <strong>Capsaicina,</strong> es principal fitometabolito presente en los especímenes de <em>Capsicum annum</em> o Ají dulce, recurso vegetal ampliamente cultivado en regiones tropicales y subtropicales, fundamentalmente por el valor organoléptico que tienen sus frutos, cuyo olor y sabor son muy apreciados para la preparación de comidas, no obstante, y de acuerdo a datos epidemiológicos reportados por la Organización Mundial de la Salud, el consumo de Ají dulce induce respuestas inmunológicas positivas en el cuerpo humano, de allí que, se recomiende su uso como tratamiento para mitigar el efecto de varias patologías.</div>
<p></p>
<div class="text-justify">El contenido total de Capsaicina, varía considerablemente de una variedad de Ají dulce a otra, sin embargo, en los últimos años se han estudiado las respuestas farmacológicas y clínicas que inducen bajas concentraciones de Capsaicina sobre el sistema cardiovascular, dérmico, gástrico, inmunológico, musculo-esquelético, y sensorial, cuyos resultados demuestran que esta fitosustancia actúa en los diferentes mecanismos fisiológicos dónde participa la prostaglandina, induciendo protección sobre problemas miocárdicos, dolores musculo-esqueléticos, artritis reumatoide, neuropatía diabética, inflamación severa, cáncer, desordenes gástricos y ulceración, desequilibrios del sistema inmunológico, afecciones asociadas a radicales libres, y problemas de obesidad.</div>
<p></p>
<div class="text-justify">Si bien, el tratamiento con capsaicina proveniente de frutos de Ají dulce (<em>Capsicum annum</em>) genera bioactividad positiva para tratar las patologías anteriormente descritas, es importante mencionar que la capsaicina proveniente de otros especímenes del género <em>Capsicum</em> con mayor nivel de pungencia, a saber; <em>C. baccatum, C. chinense, C. frutescens</em> y <em>C. pubescens,</em> suelen generar efectos tóxicos entre estos los más reportados son; irritación de la mucosa gastrointestinal, dolor del tracto respiratorio, diarrea, enrojecimiento de la piel y fatiga.</div>
<p></p>
<div class="text-justify">Es por ello, que el objetivo de la presente entrega consiste en presentar los principales atributos morfológicos vegetativos y reproductivos del Ají dulce (<em>Capsicum annum</em>), además de las respuestas fitofarmacológicas, reacciones adversas, perfil fitofarmacológico que lo diferencian del resto de los especímenes del género <em>Capsicum.</em></div>
<p></p>
<hr />
<center><h1>Características botánicas</h1></center>
<hr />
<p></p>
<h2>Taxonomía y distribución</h2>
<p></p>
<div class="text-justify">El Ají dulce, se ubicada artificialmente en la <strong>División:</strong> Magnoliophyta., <strong>Clase:</strong> Magnoliopsidad., <strong>Orden:</strong> Solanales., y <strong>Familia:</strong> Solanaceae., se trata un material vegetal de biotipo herbáceo y porte arbustivo de crecimiento anual, de origen incierto pues se asume que probablemente los materiales silvestres provienen de México o Ecuador.</div>
<p></p>
<center><img src="https://i.imgur.com/AcxfAC8.png"/></center>
<blockquote><div class="text-justify">Imagen 2. Segmento foliar de plántula en producción de <em>Capsicum annuum.</em> Autor: @lupafilotaxia.</div></blockquote></div>
<hr />
<h2>Nombres comunes</h2>
<p></p>
<div class="text-justify">La mayoría de los autores coinciden en denominar a <em>Capsicum annuum</em> de forma vernácula como Ají dulce, sin embargo, en algunos países se le suele identificar como chile.</div>
<p></p>
<center><img src="https://i.imgur.com/mXyCHud.png"/></center>
<blockquote><div class="text-justify">Imagen 3. Botón floral de <em>Capsicum annuum </em> Autor: @lupafilotaxia.</div></blockquote></div>
<hr />
<h2>Morfología vegetativa y reproductiva</h2>
<p></p>
<div class="text-justify">Los materiales silvestres y cultivados de <em>Capsicum annuum,</em> se caracterizan por presentar láminas foliares simples de morfología variada entre ovaladas, lanceoladas y oblongo/ovaladas, de filotaxia alterna, margen liso, tallos y ramas ligeramente lignificados, flores pequeñas en grupos de dos o más y de coloración blanca, púrpura a violeta, con frutos tipo baya que de acuerdo a la variedad pueden ser; largos, cilíndricos, ovoides, obtusos u oblongos y de color entre naranja a rojo al madurar, de aspecto liso y brillante, con semillas lisas y redondas con protuberancia en los bordes.</div>
<p></p>
<center><img src="https://i.imgur.com/Qpbe5S8.png"/></center>
<blockquote><div class="text-justify">Imagen 4. Fruto inmaduro de <em>Capsicum annuum.</em> Autor: @lupafilotaxia.</div></blockquote></div>
<p></p>
<hr />
<center><h1>Respuestas fitofarmacológicas</h1></center>
<hr />
<p></p>
<h2>Fitometabolitos reportados</h2>
<p></p>
<div class="text-justify">Dentro de los estudios fitoquímicos, los de mayor relevancia vinculados a respuestas fitofarmacológicas en <em>Capsicum annuum</em> se han realizado a nivel de frutos, y de acuerdo, a los resultados de estas investigaciones de corte experimental, las sustancias tipo capsaicinoides han resultado ser los principales fitometabolitos de bioactividad positiva sobre la salud, siendo la <strong>capsaicina</strong> <strong><em> ((6E)-N-(4-Hidroxi-3-metoxibencil)-8-metil-6-nonanamida)</em></strong> y la <strong><em>dihidrocapsaicina</em></strong> los capsaicinoides que exhiben mayor concentración en frutos maduros, seguidas cuantitativamente por <strong><em>nordihidrocapsaicina, homodihidrocapsaicina,</em></strong> y la <strong><em>homocapsaicina,</em></strong> mientras que los fitometabolitos reportados en menor proporción se encuentran algunos alcaloides, como la <strong><em>solanina, solanidina,</em></strong> y <strong><em>solasodina,</em></strong> [1].</div>
<p></p>
<center><img src="https://i.imgur.com/qMqny9Q.png"/></center>
<blockquote><div class="text-justify">Imagen 5. Estructura química de la Capsaicina. Diseño realizado por el Autor: @lupafilotaxia.</div></blockquote></div>
<hr />
<p></p>
<div class="text-justify">El fruto maduro de Ají dulce (<em>Capsicum annuum</em>), además de sustancias fitofarmacológicas como la capsaicina, también contiene altas concentraciones de vitamina C, que desde el punto de vista biológico deriva a partir de los pigmentos carotenoides que actúan durante la fase de madurez de los frutos, además de vitamina A, vitamina E, vitamina G, calcio, fósforo, hierro, magnesio, potasio, y selenio.</div>
<p></p>
<h2>Respuesta anticancerígena</h2>
<p></p>
<div class="text-justify">Se reporta que la capsaicina presente en los frutos de Ají dulce (<em>Capsicum annuum</em>), registra actividad citotóxica al inhibir el metabolismo celular en diferentes tejidos cancerígenos, fundamentalmente los que crecen de forma descontrolada en la región mamaria y prostática.</div>
<p></p>
<h2>Acción cardiovascular</h2>
<p></p>
<div class="text-justify">La administración de fitosustancias capsaicinoides, han mostrado efectos positivos de vasodilatación en pacientes con enfermedad coronaria, y en caso particular de la capsaicina, a nivel clínico revela acción cardiovascular sobre cardiopatías isquémicas, e hipertensión.</div>
<p></p>
<h2>Actividad analgésica y antiinflamatoria</h2>
<p></p>
<div class="text-justify">Existen fitofármacos comerciales a base de capsaicina de actividad tópica y capacidad analgésica periférica, mientras que las respuestas asociadas a dolores de cabeza, y dolores músculo-esqueléticos, la capsaicina de Ají dulce exhibe mayor efectividad durante cuadros de patogénesis inflamatorias.</div>
<p></p>
<h2>Efecto antiviral</h2>
<p></p>
<div class="text-justify">La fitosustancias capsaicinoides del Ají dulce, registran cierta capacidad para interrumpir el desarrollo de infecciones de carácter viral, al generar equilibrios homeostáticos en el sistema inmunológico, acción que desencadena la supresión de virus patogénicos en cualquier fase de infestación.</div>
<p></p>
<h2>Acción favorable en tratamientos gástricos</h2>
<p></p>
<div class="text-justify">Se conoce que la capsaicina, presente especímenes con niveles de pungencia elevados como el caso del Ají picante <em>Capsicum baccatum</em> suele ocasionar inflamación de la mucosa gástrica y la consecuente aparición de úlceras gástricas, sin embargo, la capsaicina que exhibe el Ají dulce <em>Capsicum annuum,</em> muestra capacidad bioactiva como reconstituyente de la mucosa gástrica, de allí que, se utilice como un fitofármaco en pacientes con enfermedades gastrointestinales, ya que esta fitosustancia reduce el volumen de los jugos gástricos, y simultáneamente mejora los cambios histopatológicos.</div>
<p></p>
<h2>Respuesta antiobesidad </h2>
<p></p>
<div class="text-justify">Una de las respuestas, de mayor utilidad de las fitosustancias capsaicinoides presentes en los frutos de Ají dulce <em>Capsicum annuum,</em> es la capacidad que manifiestan para regular el nivel de expresión del ARNm / LPL, o lipoproteína lipasa asociada a la ganancia de peso, de allí la razón, de porque las personas que consumen habitualmente frutos de Ají dulce, muestran una menor incidencia a sufrir de obesidad, ahora bien el efecto lipolítico de la capsaicina, se debe a su acción por termogénesis entre el tejido adiposo y las proteínas relacionadas con el metabolismo lipídico.</div>
<p></p>
<hr />
<center><h1>Uso artesanal de la capsaicina</h1></center>
<hr />
<p></p>
<div class="text-justify">El consumo de capsaicina artesanal, es el más generalizado entre los fitometabolitos de acción fitofarmacológica, esencialmente porque, los frutos de Ají dulce <em>Capsicum annuum,</em> se emplean como especia para darle sazón a las comidas, de allí que, este catalogado como el condimento de mayor uso, por ende, su amplia utilidad como alimento hace que su respuesta medicinal este activa a escala global, no obstante, parte de la producción del Ají dulce se destina para la elaboración de productos fitofarmacéuticos que inducen respuestas más rápidas.</div>
<p></p>
<hr />
<h3><center>APORTES DE ESTA PUBLICACIÓN</center></h3>
<hr />
<ul>
<li><div class="text-justify">Queda demostrado que existen efectos fitofarmacologicos asociados al fruto de Ají dulce (<em>Capsicum annum</em>), información que puede contrastarse con cada una de las inferencias experimentales y clínicas que a la fecha han reportado investigaciones bien esquematizadas, adicionalmente el manuscrito socializado precisó ampliar más tópicos de la información bibliográfica disponible, en la búsqueda por hacer digerible el contenido científico en la plataforma HIVE.</div></li>
</div></li>
</ul>
<p></p>
<hr />
<h3><center> REFERENCIAS BIBLIOGRÁFICAS CONSULTADAS Y CITADAS:</center></h3>
<hr />
<p></p>
<div class="text-justify"><strong>[1] Yánez P., Balseca D., Rivadeneira L., y Larenas C.</strong> Características morfológicas y de concentración de capsaicina en cinco especies nativas del género <em>Capsicum</em> cultivadas en ecuador. La Granja: Revista de Ciencias de la Vida. 2015; 22; 2: 12-32. <a href="https://www.redalyc.org/pdf/4760/476047267002.pdf" rel="noopener" title="This link will take you away from steemit.com">Artículo: Acceso Online</a></div>
<p></p>
<div class="text-justify"><strong>[2] Ali Esmail Al-Snafi.</strong> The pharmacological importance of capsicum species (<em>Capsicum annuum</em> and <em>Capsicum frutescens</em>) grown in Iraq. Journal of Pharmaceutical Biology. 2015; 5;3: 124-142. <a href="https://www.researchgate.net/publication/313678758_THE_PHARMACOLOGICAL_IMPORTANCE_OF_CAPSICUM_SPECIES_CAPSICUM_ANNUUM_AND_CAPSICUM_FRUTESCENS_GROWN_IN_IRAQ" rel="noopener" title="This link will take you away from steemit.com">Artículo: Acceso Online</a></div>
<p></p>
<div class="text-justify"><strong>[3] Syeda N.</strong> A Systemic Review on Phytochemistry and Pharmacological Activities of <em>Capsicum annuum.</em> Ijppr. Human. 2015; 4, 3: 51-68. <a href="http://ijppr.humanjournals.com/wp-content/uploads/2015/11/5.Syeda-Nishat-Fathima.pdf" rel="noopener" title="This link will take you away from steemit.com">Artículo: Acceso Online</a></div>
<p></p>
<div class="text-justify"><strong>[4] Alcalá C., De la Rosa L., Pedraza J., Medina O., Meza S., Wall A., Plenge L., y Álvarez E.</strong> Caracterización fitoquímica de un extracto de <em>Capsicum annuum</em> cv. “Jalapeño” y su actividad citotóxica en células 3T3-L1. Revista Mexicana de Ciencias Farmacéuticas. 2017; 48; 3: 28-36. <a href="https://www.redalyc.org/pdf/579/57956616004.pdf" rel="noopener" title="This link will take you away from steemit.com">Artículo: Acceso Online</a></div>
<p></p>
<div class="text-justify"><strong>[5] Saleh B., Omer A., and Teweldemedhin B.</strong> Medicinal uses and health benefits of chili pepper (<em>Capsicum</em> spp.): a review. MOJ Food Process Technol. 2018; 6; 4: 325‒328. <a href="http://medcraveonline.com/MOJFPT/MOJFPT-06-00183.pdf" rel="noopener" title="This link will take you away from steemit.com">Artículo: Acceso Online</a></div>
<p></p>
<div class="text-justify"><strong>[6] Delgado R., Flores D., y Villalobos E.</strong> Efecto del <em>Capsicum annum</em> L (pucunucho, ají mono) en úlcera gástrica experimental inducida en ratas. Rev Gastroenterol Peru. 2015. 35; 2: 141-50. <a href="http://www.scielo.org.pe/pdf/rgp/v35n2/a04v35n2.pdf" rel="noopener" title="This link will take you away from steemit.com">Artículo: Acceso Online</a></div>
<p></p>
<hr />
<p><center><h1>ATENCIÓN</h1></center></p>
<p><center><h2>Lectores y seguidores</h2></center></p>
<hr />
<div class="text-justify"><em> Si desean leer más artículos científicos en inglés o español, de excelente calidad académica, no duden en visitar #STEMSocial y #STEM-espanol, comunidades que promueven el contenido científico principalmente en las áreas de Ciencia, Tecnología, Ingeniería y Matemáticas.</em></div>
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<center><img src="https://i.imgur.com/qIxnkPV.png"/></center>
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