Azole
Thiazole
Zinc-Thiazole 
Epothilone
Alkaloid

Electrophile
Metallation

https://en.m.wikipedia.org/wiki/Thiazole

https://en.m.wikipedia.org/wiki/Epothilone

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Thiazoles are found in a variety of specialized products, often fused with benzene derivatives, the so-called benzothiazoles. In addition to vitamin B1, the thiazole ring is found in epothilone. Other important thiazole derivatives are benzothiazoles, for example, the firefly chemical luciferin. 

The principal mechanism of the epothilone class is the inhibition of the microtubule function.

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https://en.m.wikipedia.org/wiki/PINK1

https://en.m.wikipedia.org/wiki/Serine/threonine-specific_protein_kinase

https://en.m.wikipedia.org/wiki/Thymosin_beta-4#Tissue_regeneration

oxidised derivative of thymosin β4 (the sulfoxide, in which an oxygen atom is added to the methionine near the N-terminus) exerted several potentially anti-inflammatory effects

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niclosamide, an anthelmintic drug, was identified as a potent activator of PINK1 in cells and in neurons.

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Resistance to anti-tubulin agents: From vinca alkaloids to epothilones

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9019178/

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![20240203_204932_1.jpg](https://images.hive.blog/DQmcrVtZr9vbUUCWsyve3EnHaGWx2rSzShhqTRxCCgdEwbr/20240203_204932_1.jpg)

Coronary Artery 
Calcification
Microcalcification
Phosphorus

Coexistence of cardiac amyloidosis with coronary artery disease

Calcifications derive from the amyloid protein that has a calcium affinity which accumulates in perivascular, periductal and intralobular areas

The contribution of amyloid deposition in the aortic valve to calcification and aortic stenosis

Calcium-calcineurin signaling pathway in Candida albicans: A potential drug target

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The prion protein binds thiamine

https://febs.onlinelibrary.wiley.com/doi/full/10.1111/j.1742-4658.2011.08304.x