RE: Icosahedron by mikewick77

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icosahedron · @mikewick77 · Apr 12 '22

..

Crotalphine, a novel potent analgesic peptide from the venom of the South American rattlesnake Crotalus durissus terrificus

https://pubmed.ncbi.nlm.nih.gov/18495297/

Venom of the South American rattlesnake Crotalus durissus terrificus induces a long-lasting antinociceptive effect mediated by activation of kappa- and delta-opioid receptors.

BmK-YA, an enkephalin-like peptide in scorpion venom

https://pubmed.ncbi.nlm.nih.gov/22792309/

venom from the Asian scorpion Buthus martensii Karsch (BmK) for their abilities to activate opioid receptors, we have identified BmK-YA, an amidated peptide containing an enkephalin-like sequence.

Spider Venom Peptide Pn3a Inhibition of Primary Afferent High Voltage-Activated Calcium Channels

https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC7875911/

Voltage-gated calcium (Cav) channels, Cav1 and Cav2 mediate the high voltage-activated (HVA) calcium currents (I Ca) that orchestrate synaptic transmission in nociceptive dorsal root ganglion (DRG) neurons and are fine-tuned by opioid receptor (OR) activity.

Opiate-induced seizures: a study of mu and delta specific mechanisms

https://pubmed.ncbi.nlm.nih.gov/3015659/

Both morphine and morphiceptin produced electrical seizure activity in rats as young as 5 days after birth. The drugs produced similar seizure activity in terms of electrical morphology, observed behavior, ontogeny, threshold dose, and reversibility with small doses of naloxone. In the pharmacologic experiments, icv naloxone blocked all opiate-induced seizures.

Passage of SARS-CoV-2 in cells expressing human and mouse ACE2 selects for mouse-adapted and ACE2-independent viruses

https://www.biorxiv.org/content/10.1101/2021.12.16.473063v1

Recently Evolved Region of the “Dark Genome” Offers Clues to Treatment of Schizophrenia and Bipolar Disorder

https://scitechdaily.com/recently-evolved-region-of-the-dark-genome-offers-clues-to-treatment-of-schizophrenia-and-bipolar-disorder/

When we look outside the regions of DNA classed as genes, we see that the entire human genome can make proteins, not just the genes. We’ve found new proteins that are involved in biological processes and are dysfunctional in disorders like schizophrenia and bipolar disorder.

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@mikewick77 · Apr 21 '22 (edited)

snake & spider symbiont venom may be similar to ecoli bacteria chemical fermentation, but symbiont cannot replicate like normal bacteria within different species, because a symbiont not a free-living cell.

snake venom an identical symbiont manufacturers chemicals similar to e.coli.

Tobacco Mosaic Virus & Peptide Amphiphile make the same shape.

snake venom makes Peptide, Symbionts manufacture Peptides.

Peptide Amphiphile is a Natrual form of Hydrogel.

Peptide amphiphiles (PAs) are peptide-based molecules that self-assemble into supramolecular nanostructures including; spherical micelles, twisted ribbons, and high-aspect-ratio nanofibers.

Peptide Amphiphile

https://en.m.wikipedia.org/wiki/Peptide_amphiphile

Unusual Stability of Messenger RNA in Snake Venom Reveals Gene Expression Dynamics of Venom Replenishment

https://www.researchgate.net/publication/230645936_Unusual_Stability_of_Messenger_RNA_in_Snake_Venom_Reveals_Gene_Expression_Dynamics_of_Venom_Replenishment

..

Endosymbiont 
Symbiont 
Peptide 
Cnidaria
Hydrozoa 
Scyphozoa

https://en.m.wikipedia.org/wiki/Cnidaria

Genome Mining Reveals Endopyrroles from a Nonribosomal Peptide Assembly Line Triggered in Fungal-Bacterial Symbiosis

https://pubmed.ncbi.nlm.nih.gov/31283172/

Proteomic characterisation of toxins isolated from nematocysts of the South Atlantic jellyfish Olindias sambaquiensis 

https://www.sciencedirect.com/science/article/abs/pii/S0041010113001839

Phylogenomics provides a robust topology of the major cnidarian lineages and insights on the origins of key organismal traits

https://bmcecolevol.biomedcentral.com/articles/10.1186/s12862-018-1142-0

Alternative mRNA Splicing in Three Venom Families Underlying a Possible Production of Divergent Venom Proteins of the Habu Snake, Protobothrops flavoviridis

https://www.mdpi.com/2072-6651/11/10/581/htm

The king cobra genome reveals dynamic gene evolution and adaptation in the snake venom system

https://www.pnas.org/doi/10.1073/pnas.1314702110

Like venom coursing through the body: Researchers identify mechanism driving COVID-19 mortality

https://www.sciencedaily.com/releases/2021/08/210824135358.htm

sPLA2-IIA enzyme destroys microbial cell membranes in bacterial infections, as well as its similar genetic ancestry with a key enzyme found in snake venom.

..

Antimicrobial Resistance in Escherichia coli

https://pubmed.ncbi.nlm.nih.gov/30003866/

The intracellular function of extracellular signaling peptides

https://pubmed.ncbi.nlm.nih.gov/11587781/

Evolution Mystery: Spider Venom And Bacteria Share Same Toxin

https://www.sciencedaily.com/releases/2006/02/060202075525.htm

There’s a Perfectly Good Reason to Mass-Produce Snake Venom

https://www.theatlantic.com/science/archive/2020/01/how-make-snake-venom-without-any-snakes/605347/

Glutathione and Transition-Metal Homeostasis in Escherichia coli

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2493246/

Ascorbic acid metabolism and functions: A comparison of plants and mammals

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191929/

..

Suppression of RNA Recognition by Toll-like Receptors: The Impact of Nucleoside Modification and the Evolutionary Origin of RNA

https://www.cell.com/immunity/fulltext/S1074-7613(05)00211-6?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761305002116%3Fshowall%3Dtrue

Penn’s mRNA scientists Drew Weissman and Katalin KarikÃ³ receive the 2021 Lasker Prize, the top US award in biomedical research

https://abigailgroffcom.b-cdn.net/penns-mrna-scientists-drew-weissman-and-katalin-kariko-receive-the-2021-lasker-prize-the-top-us-award-in-biomedical-research/

Matrix protein of rabies virus is responsible for the assembly and budding of bullet-shaped particles and interacts with the transmembrane spike glycoprotein G

https://pubmed.ncbi.nlm.nih.gov/9847327/

Designing Signal Peptides for Efficient Periplasmic Expression of Human Growth Hormone in Escherichia coli

https://pubmed.ncbi.nlm.nih.gov/28851205/

Thioredoxin-linked reductive inactivation of venom neurotoxins

https://pubmed.ncbi.nlm.nih.gov/8135548/

Bacterial ribonucleases and their roles in RNA metabolism

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6776250/

..

Mycoplasma spp. in captive snakes (Boa constrictor and Bothrops atrox) from Brazil

..

Slime mold

https://en.m.wikipedia.org/wiki/Slime_mold

Slime molds begin life as amoeba -like cells. These unicellular amoebae are commonly haploid and feed on bacteria. These amoebae can mate if they encounter the correct mating type and form zygotes that then grow into plasmodia. These contain many nuclei without cell membranes between them.

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@mikewick77 · Apr 20 '22 (edited)

![Plot-of-synteny-between-the-genomes-of-Ca-Rickettsiella-viridis-and-R-grylli.png](https://images.hive.blog/DQmemznC74hXoRDpnWD5RYwQgXfLkXKuWf724pYhrwqbr5H/Plot-of-synteny-between-the-genomes-of-Ca-Rickettsiella-viridis-and-R-grylli.png)

Snake Venom
Phosphodiesterase
5’-nucleotidase
5’-mononucleotides
3’-OH-terminated
riboand deoxyribo-oligonucleotides

https://www.innov-research.com/products/snake-venom-phosphodiesterase-i-purified-lyophilized

The enzyme has an optimal pH range of 9.8-10.4 and a molecular weight of 115 kDa. It is inhibited by reducing agents such as glutathione, cysteine and ascorbic acids and completely inhibited by 5 mM EDTA. ATP, ADP and AMP are partial inhibitors. The enzyme has an absolute requirement for Mg2+.

Source:
Rattlesnake Venom
Storage Conditions: -20°C

Dynabeads
Magnetic Beads
Thermo Fisher

https://www.thermofisher.com/us/en/home/brands/product-brand/dynal.html

https://en.m.wikipedia.org/wiki/Phosphodiesterase

https://en.m.wikipedia.org/wiki/D-dimer

Botox is a drug made from a toxin produced by the bacterium Clostridium botulinum.

Snake venom is used as a wrinkle-reducing treatment, but it is supposed to be put in a cream that's used on the surface of the skin.

cone snail venom, Botox alternative, Also called snail venom conopeptide or MU-conotoxin, this synthetic ingredient mimics the effects of cone snail venom.

Genetic engineering and biological weapons

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1326447/

USSR 'invisible anthrax', resulting from the introduction of an alien gene into Bacillus anthracis that altered its immunological properties. Existing vaccines proved to be ineffective against this new genetically engineered strain.

MRSA
Superantigen

https://en.m.wikipedia.org/wiki/Superantigen

https://en.m.wikipedia.org/wiki/Staphylococcus_aureus

https://www.microscopemaster.com/alphaproteobacteria.html

Recently Evolved Francisella-Like Endosymbiont Outcompetes an Ancient and Evolutionarily Associated Coxiella-Like Endosymbiont in the Lone Star Tick (Amblyomma americanum) Linked to the Alpha-Gal Syndrome

https://www.frontiersin.org/articles/10.3389/fcimb.2022.787209/full

Which bacterium is the ancestor of the animal mitochondrial genome?

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC45536/

Mimicking Human Brain Development Using Organoids

https://www.news-medical.net/news/20180907/Mimicking-Human-Brain-Development-Using-Organoids.aspx

Organoids of Human Endometrium: A Powerful In Vitro Model for the Endometrium-Embryo Cross-Talk at the Implantation Site

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291023/

they are blending chimera Organoids with humans & calling it medicine, this is gain of function.

Organoid cells are unusual, immortal cell line hela, hydra ect.. stem cells.

reminds me of endosymbionts & symbiogenesis of bacteria into biological cells, aka chimera viruses is the chimera organoid cell line code, venom acts as the alkaloid.

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@mikewick77 · Apr 12 '22

![Screenshot_20220411-202903_Samsung Internet Beta_1.jpg](https://images.hive.blog/DQmeiJ2vf9b6gMPQKNZ7XzwkqVyps5wABXdDktka2DDCfz3/Screenshot_20220411-202903_Samsung%20Internet%20Beta_1.jpg)

Dalazatide (ShK-186)
https://pubchem.ncbi.nlm.nih.gov/compound/Dalazatide

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@mikewick77 · Apr 21 '22 (edited)

![20220418_111335.jpg](https://images.hive.blog/DQmYubmc4YgGmqLeVTN3Q6igQuocnpVDesFMCVuFVdcUQ8a/20220418_111335.jpg)

bacteria venom, how e coli melts tissue like venom.

my guess is they have some kind of common bacteria that can manufacture snake venom protein or peptide, under specific circumstances, or by wireless signaling.

either E.Coli or Bacillus Subtilis, but would need to be isolated & fermentation analyzed.

mRNA may have a similar process as venom synthesis or gain of function, using venom, alkaloids, yeast & bacteria.

bacteria in the lizard mouth digests the food, similar to why snakes & spiders use venom, to break down tissue.

viruses have a secondary bacteria co-infection, but never get linked to the origin of the infection.

yet some bacteria infections behave kike viruses & are still nearly uncureable, such as with lyme, or GMO GWS.

it seems possible they just made Lyme more dangerous & made up a big story.

biggest clue is mycoplasma incognitus can hide, and require very special processes to isolate, yet if nobody is looking for it, how will it ever be found?

Incognitus is an old strain.

"Evolution Mystery: Spider Venom And Bacteria Share Same Toxin"

then take that bacteria genome & put into mycoplasma laboratorium or incognitus.

put this together and make it wireless compatible using nano supercapacitor that recharge via luciferase bioluminance.

i still think mimicking bacteria can make the same peptide spikes.

either mycoplasma or mutated gut bacteria like ecoli.

mimicking venom peptide in plain sight, where nobody is looking, not so much mRNA factory.

dormancy of mycoplasmas & alphaproteobacteria are another clue.

gulf war syndrome & chronic fatigue has similar symptoms as long covid, mycoplasma incognitus & lyme probably manufactures similar venom peptides.

why do i keep getting the impression snake venom Phosphodiesterase is like being injected with pure white or yellow Phosphorus?

what if ..

HIV is mycoplasma with Anthrax codons.

GWS is mycoplasma with Botulinum codons.

CFS is mycoplasma with Ecoli codons.

venom being manufactured via weaponized mycoplasma incognitus (synthia) anthrax, gulf war syndrome 2.0

GWS
Gulf War Syndrome

CFS
Chronic Fatigue Syndrome

the people who got most affected by covid were already struggling with weaponized mycoplasma infections.

GWS 2.O

Mycoplasma Incognitus
Mycoplasma Synthia

programmable bacteria, wireless transmission to manufacture different chemical compounds or peptides, are nearly indestructible, likely attach to mitochondria sending out spores that appear virus-like, 20 year dormancy, hide in bone marrow & brain, amoeba amorphous, stealth pathogen.

ADAM biohacking, biological DNA computers, using hydrogel, nanodots, magnetic beads, graphine, microfiber tubes.

all of this requires a microbe capable of manufacturing anything via wireless.

nearly indestructible, likely extremophile & immortal cell lines.

Cnidaria
Polypodium
Myxozoa
Myxovirus
Myxosporea

HeLa
Immortal Cell Line

Tubulin (HeLa)
HLA-DR (DR2)

i think the world is being tested with Blockchain DNA, with a master control via CERN.

is it possible the Lipid Nano Particles can be an un-activated Synthia Laboratorium Mycoplasma/Incognitus, resting dormant, capable of biological mimicking, programmable vaxx?

Minimal Genome
Stealth Pathogen
Gulf War Syndrome 2.0

i thin they finally combined virus with bacteria into a totally synthetic lifeform, and nobody will ever find it, becaus they cant understand what it is.

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@mikewick77 · May 2 '22 (edited)

Vitamin C
Glutathione
NAC
Nicotine
Melatonin
Hydroxychloroquine
Zinc

..

![imgsrv-77.png](https://images.hive.blog/DQmfHrFhBJs3yT8a78mVYvWTYV3FaYqp1Yee3MS2GDtwb1u/imgsrv-77.png)
Acetone

![imgsrv-76.png](https://images.hive.blog/DQmNuTgjYSzDr98fWLoRaRtyh8KwvA6BYiHo14xYAecy46j/imgsrv-76.png)
Bicarbonate

![imgsrv-67.png](https://images.hive.blog/DQmVBXwYV9kM5JmNPMRLzFSRV5ZVzDMsFDn1UC7G8AJwT2Y/imgsrv-67.png)
Vitamin C




![imgsrv-68.png](https://images.hive.blog/DQmSTD2y5Ttn559QLjnCdNV9ojhnSXBwWiya7sYwX2STTuN/imgsrv-68.png)
N-Acetyl-L-cysteine


![imgsrv-69.png](https://images.hive.blog/DQmPVa9XRTPDSZQBX41mL45ipHKwHPEVgq2o1SU5PSh338N/imgsrv-69.png)
Glutathione


![imgsrv-70.png](https://images.hive.blog/DQmVgPE2kPdSFhFJLnEtokDsbi9JPXU1h1ea8SrewZBgdAp/imgsrv-70.png)
Lipoic acid

![imgsrv-71.png](https://images.hive.blog/DQmcYBsVBmo4Bc1jtGWBqALjt39wRJnZhPFvAeNywwabnVV/imgsrv-71.png)
Nicotine


![imgsrv-66.png](https://images.hive.blog/DQmNs7soogHn6iAPNaYLVQdNuMjAyo94YhuEAQb9EdCUWcC/imgsrv-66.png)
Hydroxychloroquine

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@mikewick77 · Apr 26 '22 (edited)

![j35-rssr.gif](https://images.hive.blog/DQmVpkmbGoTqpkXUdtgWACLNphSopDQxjF4CpxkQXK3oFUp/j35-rssr.gif)

Reducing Agent
Electron Donor
Hydroxyl Radical
Glutathione-Ascorbate Cycle

Glutathione 
Cysteine 
Ascorbic Acid

Uronic Acid
Pentose (5 Simple Sugar)
Hexuronic Acid
Hexose (6 Simple Sugar)
Gulonolactone Oxidase

Redox
Chelation
Ionophore Metallation

Reduction is loss of oxygen atoms and gain of electrons and hydrogen. While oxidation is gain of oxygen and loss of electrons and hydrogen

..

Methodology for Enzymes

https://biocyclopedia.com/index/plant_protocols/enzymes/ascorbic_acid_oxidase.php

Reducing Agent

https://en.m.wikipedia.org/wiki/Reducing_agent

Electron Donor

https://en.m.wikipedia.org/wiki/Electron_donor

Glutathione-Ascorbate Cycle

https://en.m.wikipedia.org/wiki/Glutathione-ascorbate_cycle

Hydroxyl Radical

https://en.m.wikipedia.org/wiki/Hydroxyl_radical

Electron Transport Chain ETC

https://en.m.wikipedia.org/wiki/Electron_transport_chain

..

Plant polyphenols as electron donors for erythrocyte plasma membrane redox system: validation through in silico approach

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3355021/

Fast Antioxidant Reaction of Polyphenols and Their Metabolites

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8389220/

Ascorbate Biosynthesis in Mitochondria Is Linked to the Electron Transport Chain between Complexes III and IV

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC59007/

https://en.m.wikipedia.org/wiki/L-gulonolactone_oxidase

..

Heterocyclic Compound
Pyrrole

https://en.m.wikipedia.org/wiki/Heterocyclic_compound

https://en.m.wikipedia.org/wiki/Pyrrole

..

Pineapple
Enzyme

Vitamin C: 88% DV
Manganese: 109% DV
Copper: 20% DV

..

Suramin

trypanosomal glycolytic enzyme lipoprotein

https://en.m.wikipedia.org/wiki/Suramin

The mechanism of action for suramin is unclear, but it is thought that parasites are able to selectively uptake suramin via receptor-mediated endocytosis of drug that is bound to low-density lipoproteins and, to a lesser extent, other serum proteins. Once inside parasites, suramin combines with proteins, especially trypanosomal glycolytic enzymes, to inhibit energy metabolism.

https://en.m.wikipedia.org/wiki/Proteolipid

https://en.m.wikipedia.org/wiki/Lipoprotein

https://en.m.wikipedia.org/wiki/Lipoprotein_lipase

https://en.m.wikipedia.org/wiki/Lipopolysaccharide

https://en.m.wikipedia.org/wiki/Toll-like_receptor

..

https://en.m.wikipedia.org/wiki/Lysis

https://en.m.wikipedia.org/wiki/Protoplast

https://en.m.wikipedia.org/wiki/Spheroplast

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@mikewick77 · Apr 22 '22 (edited)

![imgsrv-73.png](https://images.hive.blog/DQmb6hLtdSbjwgdceKtwdyixiFe4JwGuzNZRNKTaC5ruHX4/imgsrv-73.png)


Proton Ionophore
Calcium Ionophore A23187

https://pubchem.ncbi.nlm.nih.gov/compound/Calcium-ionophore-A23187

Discovery of a sugar-based nanoparticle universally existing in boiling herbal water extracts and their immunostimulant effect

https://www.sciencedirect.com/science/article/pii/S2405580818301766

Sugar-based amphiphilic nanoparticles arrest atherosclerosis in vivo

https://www.pnas.org/doi/10.1073/pnas.1424594112

Ionophores – Channels and Pumps

https://fieldsofconsciousness.wordpress.com/2018/06/16/ionophores-channels-and-pumps/

Ionophore-resistant mutant of Toxoplasma gondii reveals involvement of a sodium/hydrogen exchanger in calcium regulation

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172388/

properties (22)