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| title | "부모에게서 유전되는 자폐 위험요인 유전자" |
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| body | "<p> ※ 자폐 아동을 키우는 부모로서 공부한 내용을 공유합니다. </p>
<p><a href="https://www.ncbi.nlm.nih.gov/pubmed/31398340">https://www.ncbi.nlm.nih.gov/pubmed/31398340</a></p>
<p>최근 자폐 관련 연구를 보면 뇌와 유전자에 집중하는 것을 확인할 수 있다. 결국 자폐라는 건 태어나면서 갖게 되는 선천적인 장애라는 것이다. 하지만 그 원인을 아직 알지 못하기 때문에 그 원인을 규명하려는 연구는 지속되고 있다. 자폐의 원인이 확인되면 언젠가 치료할 수 있는 방법을 찾을 수도 있기 때문이다.</p>
<p>이 연구에 의하면 자폐가 발생한 가정은 simplex family와 multiplex family로 나뉠 수 있다. simplex family는 한 아이만 자폐 아동인 경우를 말하고, multiplex family는 두 아이 이상이 자폐 아동인 가정을 의미한다. 그리고 연구는 493 multiplex family 가정을 대상으로 총 2,308명의 부모와 자녀의 전체 게놈 순서를 분석했다.</p>
<p>분석에는 the transmission and de novo association, 줄여서 TADA라고 불리는 테스트를 활용했는데, 이 테스트는 부모로부터 물려받은 유전자와 de novo mutation를 구분하는 테스트이다. de novo mutation은 수정 이후에 생기는 유전자 변이를 의미한다. 이 연구는 자폐와 관련된 유전자만 분석을 실시했다.</p>
<p>그 결과, 69개의 유전자를 확인했고, 이 중 53개 유전자는 simplex family 가정 연구에서도 확인된 유전자였다. 나머지 13개의 유전자는 multiplex family 가정에서만 발견되었는데, 이 유전자들은 모두 부모로부터 직접 물려받은 유전자였다. 이 13개의 유전자가 직접 부모로부터 물려받은 유전자라는 사실은 주목할 만한 부분이다. </p>
<p>무슨 결론을 내리기는 어려운 발견이지만 한 아이 자폐 가정과 두 아이 이상 자폐 가정 사이의 유전적 패턴의 차이를 발견했다는 점에는 의미 있는 연구라고 할 수 있을 것 같다.</p>
<p>퍼즐 한 조각 맞춘 기분이다.</p>
<br /><center><hr/><em>Posted from my blog with <a href='https://wordpress.org/plugins/steempress/'>SteemPress</a> : http://filtered.co.kr/index.php/2019/09/25/transmission-and-de-novo-mutation/ </em><hr/></center> " |
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| 16. | | ref_block_num | 9,673 |
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| ref_block_prefix | 54,735,859 |
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| expiration | 2019-09-24 19:23:21 |
|---|
| operations | | 0. | | 0. | custom_json |
|---|
| 1. | | required_auths | [] |
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| required_posting_auths | |
|---|
| id | nextcolony |
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| json | {"username":"rockhounds","type":"buildship","command":{"tr_var1":"P-ZE1134UJKIO","tr_var2":"corvette"}} |
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| extensions | [] |
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| transaction_id | 9bcba89186861228869db323bc300d38cbb423ed |
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| block_num | 36,709,835 |
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| transaction_num | 16 |
|---|
|
|---|
| 17. | | ref_block_num | 9,652 |
|---|
| ref_block_prefix | 2,375,511,582 |
|---|
| expiration | 2019-09-24 19:32:45 |
|---|
| operations | | 0. | | 0. | custom_json |
|---|
| 1. | | required_auths | [] |
|---|
| required_posting_auths | |
|---|
| id | sm_submit_team |
|---|
| json | {"trx_id":"3c63183fc32651be50805050ae0c8ad652493bfc","team_hash":"199c6dac4cd5546eacc1c86ffdcff5df","summoner":"C1-27-6ALOR09CJK","monsters":["C1-30-CHVWAHZN4W","C1-24-OQWNJBC8BK","C1-62-HFNU6HK2EO","C1-63-A88H7WY5TC"],"secret":"XwYc5AP4Of","app":"steemmonsters/0.7.0"} |
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| extensions | [] |
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| signatures | | 0. | 2079f9e7b1d3668066b7b1c2453e0ab876bddf9f485a066d0d2181ca82196ec6d660d1242ae1d05f8b4d0bb597a6592548ccb12b7bfd9db09a2e79ddfa1aaf2132 |
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| transaction_id | b7de28d0c258676ed8c15a179a19f5e8e32cb39f |
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| block_num | 36,709,835 |
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| transaction_num | 17 |
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|
|---|
| 18. | | ref_block_num | 9,673 |
|---|
| ref_block_prefix | 54,735,859 |
|---|
| expiration | 2019-09-24 19:23:22 |
|---|
| operations | | 0. | | 0. | vote |
|---|
| 1. | | voter | chaunter |
|---|
| author | oldhearted |
|---|
| permlink | steem-monster-20190923-qcd4bzjp |
|---|
| weight | 10,000 |
|---|
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|---|
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|---|
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|---|
| extensions | [] |
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| signatures | | 0. | 1f6438aec5deb76a2afc67c2957a8d19866eac5dab2ac0a06aec35230eb08d6b4b744b44fed33a0bbb608986a6496eeb111b1a38f459408521508acbe2bc364bc8 |
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| transaction_id | 7e13494ee0c0eed3a3ce0c58c735f92580905f28 |
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| block_num | 36,709,835 |
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| transaction_num | 18 |
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|
|---|
| 19. | | ref_block_num | 9,653 |
|---|
| ref_block_prefix | 2,717,252,671 |
|---|
| expiration | 2019-09-24 19:32:51 |
|---|
| operations | | 0. | | 0. | claim_reward_balance |
|---|
| 1. | | account | rafaljakobsen |
|---|
| reward_hive | 0.000 HIVE |
|---|
| reward_hbd | 0.000 HBD |
|---|
| reward_vests | 3.958003 VESTS |
|---|
|
|---|
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|---|
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|---|
| extensions | [] |
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| signatures | | 0. | 2048c9fdc6410a1b1b4d1e443c6f3a4afec122227cf78f746bf23832b6c49d22bd7ff3bac78fcb91cc5dd6ea4bbeb860c81675a90d21cf84c0fe8c9da27d9e83e2 |
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|---|
| transaction_id | 7da565b929b0afc3ef8a735b7b652bb6ba640166 |
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| block_num | 36,709,835 |
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| transaction_num | 19 |
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|
|---|
| 20. | | ref_block_num | 9,653 |
|---|
| ref_block_prefix | 2,717,252,671 |
|---|
| expiration | 2019-09-24 19:32:51 |
|---|
| operations | | 0. | | 0. | claim_reward_balance |
|---|
| 1. | | account | sugandhaseth |
|---|
| reward_hive | 0.254 HIVE |
|---|
| reward_hbd | 0.000 HBD |
|---|
| reward_vests | 676.817822 VESTS |
|---|
|
|---|
|
|---|
|
|---|
| extensions | [] |
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| signatures | | 0. | 1f61adb73d8ab960a709bfcac22be590dbce3bdcb8553096ca791c9112002b13a35165063df6ad69e5b541249c1c4cfd65a890d3affada9ce14369ac207f97c2d8 |
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|---|
| transaction_id | 6d3257c167059987fa0e78925c88b4ae4e23a1bc |
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| block_num | 36,709,835 |
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| transaction_num | 20 |
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|
|---|
| 21. | | ref_block_num | 9,652 |
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| ref_block_prefix | 2,375,511,582 |
|---|
| expiration | 2019-09-24 19:32:45 |
|---|
| operations | | 0. | | 0. | custom_json |
|---|
| 1. | | required_auths | [] |
|---|
| required_posting_auths | |
|---|
| id | sm_find_match |
|---|
| json | {"match_type":"Ranked"} |
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|---|
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| extensions | [] |
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| signatures | | 0. | 1f5b5ad75fbcf620af810a2104cfa0e32a185728c990d3b56828ee91966685f9b038928c90d0fd33c286fe146823fd5e868833c2389d3a38ee133d43a166ec103b |
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|---|
| transaction_id | 99c3d4abb04776be7398325790c2988e602e3964 |
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| block_num | 36,709,835 |
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| transaction_num | 21 |
|---|
|
|---|
| 22. | | ref_block_num | 9,653 |
|---|
| ref_block_prefix | 2,717,252,671 |
|---|
| expiration | 2019-09-24 19:32:51 |
|---|
| operations | | 0. | | 0. | transfer |
|---|
| 1. | | from | fullcoverbetting |
|---|
| to | epicdice |
|---|
| amount | 0.600 HIVE |
|---|
| memo | "Above 56" |
|---|
|
|---|
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|---|
|
|---|
| extensions | [] |
|---|
| signatures | | 0. | 1f35b4f61dda8b0b320797fbb411f53e1f15bb7b4ab99617ad8e0c2918a0eb6a2378b86f95b0022bdbbebca6d1c7a1bdfc5027f73ffc36bc061db9e28405f87e3c |
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|---|
| transaction_id | b3996efb23a77fbb2e728b4b0ed667526b407d40 |
|---|
| block_num | 36,709,835 |
|---|
| transaction_num | 22 |
|---|
|
|---|
| 23. | | ref_block_num | 9,673 |
|---|
| ref_block_prefix | 54,735,859 |
|---|
| expiration | 2019-09-24 19:23:22 |
|---|
| operations | | 0. | | 0. | vote |
|---|
| 1. | | voter | telephote |
|---|
| author | scattered |
|---|
| permlink | steem-monster-20190920-sahqziz5 |
|---|
| weight | 10,000 |
|---|
|
|---|
|
|---|
|
|---|
| extensions | [] |
|---|
| signatures | | 0. | 2030a02a6a511bc6f74581e31874639c143380aa5a239ebb4dac4923f292d72df02253f10e32f59a7267c7d20f5e00a3295ac42af4a7895d18008f1d67c2bec8e1 |
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|---|
| transaction_id | 29325c8c163f16e1947d53c92606bce54d01a76c |
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| block_num | 36,709,835 |
|---|
| transaction_num | 23 |
|---|
|
|---|
| 24. | | ref_block_num | 9,673 |
|---|
| ref_block_prefix | 54,735,859 |
|---|
| expiration | 2019-09-24 19:23:22 |
|---|
| operations | | 0. | | 0. | custom_json |
|---|
| 1. | | required_auths | |
|---|
| required_posting_auths | [] |
|---|
| id | scot_claim |
|---|
| json | {"symbol":"CTP","type":"mining","N":20,"staked_mining_power":3637.9060000000004,"winner":["videosteemit","blainjones","trafficinsider","reefe","trafficinsider","cryptofiloz","steem.leo","richardtaylor","trafficinsider","trafficinsider","xyzashu","russellstockley","trafficinsider","reefe","trafficinsider","communitybank","richardtaylor","junior182","bwar","trafficinsider"],"claim_token_amount":1.26,"trx_id":"a8db675347ba6c25c439419dbe8f304fda96c6fe","block_num":36709827,"N_accounts":54} |
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|---|
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|---|
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|---|
| extensions | [] |
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| signatures | | 0. | 1f2de019afacfa93e6084491a4997f115a4414c1165617250c50573afa0225997c328b1d27c4525b416c79b240de588fc1c2942a251d70a9337c1fa28cda26219a |
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|
|---|
| transaction_id | 4f35a6645b3c03717c3994ddb751bccd151170dd |
|---|
| block_num | 36,709,835 |
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| transaction_num | 24 |
|---|
|
|---|
| 25. | | ref_block_num | 9,652 |
|---|
| ref_block_prefix | 2,375,511,582 |
|---|
| expiration | 2019-09-24 19:32:48 |
|---|
| operations | | 0. | | 0. | custom_json |
|---|
| 1. | | required_auths | [] |
|---|
| required_posting_auths | |
|---|
| id | sm_submit_team |
|---|
| json | {"trx_id":"5a40313e37e67d0f28373e57131ad97266f84bdf","team_hash":"71fc7a25eb26e540b3aa06143c3064b2","summoner":"G1-38-7P4WQSRD8W","monsters":["G3-101-Q2LMLYI2AO","G1-37-FOBJ9ETDTS","G2-118-TAACWHJTZ4","G1-42-12V6UK8VA8","G1-34-18D857GUCW","G1-39-688OT0S51C"],"secret":"yzla9Yk5mM","app":"steemmonsters/0.7.0"} |
|---|
|
|---|
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|---|
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|---|
| extensions | [] |
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| signatures | | 0. | 205c6b6beb0ded1dac86014400c2c928a477bae68773b017149ca902b52bb5916071d4920524d422bab19b7262cc673f25cbb9fed7288dccab64e91f495dace1c4 |
|---|
|
|---|
| transaction_id | 042e53c359b92bc04e15e66ce4a788dc6aa90175 |
|---|
| block_num | 36,709,835 |
|---|
| transaction_num | 25 |
|---|
|
|---|
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|---|
hiveblocks