Viewing a response to: @mikewick77/h5r2n
Chrétien & Mbikay Quercetin PCSK9 Inhibitor https://www.mcgilltribune.com/sci-tech/montreal-researchers-propose-a-treatment-for-covid-19-170320/ "A cell has a lock, and the virus has a key [to enter and infect the cell], But quercetin puts glue in the lock" “[Quercetin] costs peanuts compared to the antivirals that are on the market, which cost sometimes $1000 [per] shot,” Chrétien said. “Two months ago, you could have a one day treatment [of over-the-counter quercetin] for two dollars.” .. https://www.medicalnewstoday.com/articles/323037#health-benefits https://medium.com/randy-s-club/18-natural-supplement-that-can-enhance-the-benefits-of-natural-cannabinoids-from-hemp-9439ba6a5b11 https://www.student-baba.com/2019/07/vitamins-produced-by-microbial.html?m=1 https://www.longdom.org/open-access/increase-of-rutin-quercetin-and-antioxidant-activity-during-germinated-buckwheat-fagopyrum-esculentum-moench-fermentation-2167-7972-1000147.pdf Bioconversion of Kaempferol and Quercetin Glucoside https://www.mdpi.com/2311-5637/4/4/102/htm .. https://en.m.wikipedia.org/wiki/Ionophore https://en.m.wikipedia.org/wiki/Flavonols https://en.m.wikipedia.org/wiki/Aglycone https://en.m.wikipedia.org/wiki/Glucoside https://en.m.wikipedia.org/wiki/Acylation https://en.m.wikipedia.org/wiki/Ester https://en.m.wikipedia.org/wiki/Lipid https://en.m.wikipedia.org/wiki/Rutin https://en.m.wikipedia.org/wiki/Kaempferol Bioconversion of Kaempferol and Quercetin Glucoside Glucoside Aglycone Acylation Ester Lipid .. going threw the process, bacteria & yeast both alter the process in so many ways, its almost impossible to clearly understand what is going on. i dont trust plant, vitamin or medical sources, specifically if the supply chain is broken, we need the manufacturing process. .. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6928927/ flavonols and flavones in tea are mainly found as glycosides, and their types and compositions vary with tea type and cultivar [2,3]. Aglycones of flavonols such as kaempferol, myricetin, and quercetin as well as their glycosides have comparable or higher antioxidant capacities than that of vitamin C. Quercetin 4-glycoside is catabolized through ring fission by intestinal bacteria into phenolic acids, such as 3,4-dihydroxyphenylacetic acid, which has higher biological activities, such as antioxidant effects, than its parent molecule. Furthermore, it has been reported that a relatively large portion of ingested rutin remains intact in the ileal fluid and that rutin metabolism occurs mainly via microbial biotransformation in the large intestine. .. The biosynthesis of kaempferol occurs in four major steps: 1) Phenylalanine is converted into 4-coumaroyl-CoA. 2) 4-coumaroyl-CoA combines with three molecules of malonyl-coA to form naringenin chalcone (tetrahydroxychalcone) through the action of the enzyme chalcone synthase. 3) Naringenin chalcone is converted to naringenin and then a hydroxyl group is added to form dihydrokaempferol. 4) Dihydrokaempferol has a double bond introduced into it to form kaempferol. The amino acid phenylalanine is formed from the Shikimate pathway, which is the pathway that plants use in order to make aromatic amino acids. This pathway is located in the plant plastid, and is the entry to the biosynthesis of phenylpropanoids. The phenylpropanoid pathway is the pathway that converts phenylalanine into tetrahydroxychalcone. Flavonols, including kaempferol, are products of this pathway. .. Phenylalanine Coumaroyl Malonyl Naringenin Chalcone Hydroxyl Dihydro Kaempferol
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 Quinone vs Quinine both have a direct connection with: Epinephrine Adrenaline Adrenochrome .. Quinones https://www.sciencedirect.com/topics/neuroscience/quinones https://neurohacker.com/what-you-can-gain-from-taking-pyrroloquinoline-quinone-pqq Pyrroloquinoline quinone (PQQ) is a "quinone," which is a big family of compounds that also includes vitamin K and CoQ10. Quinine is not in the quinone family. It is not chemically related to PQQ and does not have any functional actions in common with PQQ. .. https://wikidiff.com/quinone/quinine .. Pyrroloquinoline Quinone https://pubchem.ncbi.nlm.nih.gov/compound/Pyrroloquinoline-quinone Chloroquine https://pubchem.ncbi.nlm.nih.gov/compound/2719 Kaempferol https://pubchem.ncbi.nlm.nih.gov/compound/5280863 Ubiquinone https://pubchem.ncbi.nlm.nih.gov/compound/ubiquinone .. Quinine is used for its toxicity to the malarial pathogen, Plasmodium falciparum, by interfering with the parasite's ability to dissolve and metabolize hemoglobin. Inhibits nucleic acidand protein synthesis, and inhibits glycolysis. Inhibition of hemozoinbiocrystallization in the heme detoxification pathway, which facilitates the aggregation of cytotoxicheme. .. https://en.m.wikipedia.org/wiki/Quinine_total_synthesis Quinoline Quinone (PQQ) https://www.nootropedia.com/pqq/ Ubiquinone Quinone (Q10) https://www.nootropedia.com/coq10/ .. Role of Nicotinamide Quinone Oxidoreductase 1 (NQO1) in Protection against Toxicity of Electrophiles and Reactive Oxygen Intermediates https://www.sciencedirect.com/science/article/pii/S0076687904820196 NAD(P)H Dehydrogenase (quinone) https://en.m.wikipedia.org/wiki/NAD(P)H_dehydrogenase_(quinone) .. Quercetin Quinone Ubiquinone Kaempferol Nicotinamide Menaquinone .. Ubiquinone Metabolic engineering of coenzyme Q by modification of isoprenoid side chain https://www.sciencedirect.com/science/article/pii/S0014579306000639 isoprenoid mevalonic acid pathway ternary complex .. Reduced Nicotinamide Adenine Dinucleotide (Phosphate) Dehydrogenase (Quinone) https://www.sciencedirect.com/topics/neuroscience/reduced-nicotinamide-adenine-dinucleotide-phosphate-dehydrogenase-quinone extreme halophiles halophilic bacteria electron transport proteus rettgeri .. Inhibition of Mammalian Thioredoxin Reductase by Some Flavonoids: Implications for Myricetin and Quercetin Anticancer Activity https://cancerres.aacrjournals.org/content/66/8/4410 flavones flavonols anthocyanidins isoflavones flavonols TrxR/Trx system pro-oxidant TrxR NADPH-dependent homodimers .. The Selenium-independent Inherent Pro-oxidant NADPH Oxidase Activity of Mammalian Thioredoxin Reductase and Its Selenium-dependent Direct Peroxidase Activities https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2898413/ Thioredoxin Reductase https://en.m.wikipedia.org/wiki/Thioredoxin_reductase Ribonucleotide reductase https://en.m.wikipedia.org/wiki/Ribonucleotide_reductase Nicotinamide Adenine Dinucleotide Phosphate https://en.m.wikipedia.org/wiki/Nicotinamide_adenine_dinucleotide_phosphate Hydroxycarbamide https://en.m.wikipedia.org/wiki/Hydroxycarbamide Suramin https://en.m.wikipedia.org/wiki/Suramin Gallium https://en.m.wikipedia.org/wiki/Gallium Hemozoin https://en.m.wikipedia.org/wiki/Hemozoin Heme https://en.m.wikipedia.org/wiki/Heme Biocrystallization https://en.m.wikipedia.org/wiki/Biocrystallization Ionophore https://en.m.wikipedia.org/wiki/Ionophore .. Fluorescence https://en.m.wikipedia.org/wiki/Fluorescence Flavonoid https://en.m.wikipedia.org/wiki/Flavonoid Quinine https://en.m.wikipedia.org/wiki/Quinine Tonic Water https://en.m.wikipedia.org/wiki/Tonic_water Fluorite https://en.m.wikipedia.org/wiki/Fluorite Calcium Fluoride https://en.m.wikipedia.org/wiki/Calcium_fluoride Zinc Sulfide https://en.m.wikipedia.org/wiki/Zinc_sulfide .. XMRV (Lyme) Mycoplasma Protozoa from contaminated blood supplies & vaccines, gulf war disease chimera. corona was specifically made to exploit or trigger this pre-existing parasitic illness. malaria is a protozoa apicoplast symbiogenesis, a parasite. cure to kovid is the cure to cancer.. fermentation of bacteria & yeast SCOBY. converts Ionized minerals into ionophores that bind to the compounds & toxins within mitochondria & cellular respiration. simple ingredients: bacillus subtilis (probiotics) wine yeast (apple cider vinegar) raw honey (sugar & enzymes) multivitamin (minerals) chemicals manufactured by microbes clean the system & assist mitochondria. .. Quinine vs Quinone Quinine Chlorine Hydroxychloroquine vs Quinone Quercetin Ubiquinone Kaempferol Nicotinamide Menaquinone B3 Nicotinamide K2 Menaquinone Q10 Ubiquinone Nicotine (Quinone) Mena (Quinone) Ubi (Quinone) .. Quinine vs Quinone Quin(i)ne Quin(o)ne I/O Input/Output https://youtu.be/hGJsUrvBW4k
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Quinine Not to be confused with: Quinone Quinidine Quinoline just occurred to me, Hydroxychloroquine is going into 2 distinctly different directions. Quercetin Quinine is it one, or the other, or both? im at my ends on this, almost 8 months obsessing on Kovid, i need to run away. .. https://en.m.wikipedia.org/wiki/Quinone https://en.m.wikipedia.org/wiki/Quinidine https://en.m.wikipedia.org/wiki/Quinoline .. https://en.m.wikipedia.org/wiki/Vitamin_P https://en.m.wikipedia.org/wiki/Flavonoid https://en.m.wikipedia.org/wiki/Flavonoid_alkaloid .. Quercetin plant flavonol (alkaloid) Quinine bark of the cinchona tree (quinidine) Quinidine bark of the cinchona (quinine) Quinoline alkaloid found in plants (quinine) Quinone aromatic compounds (ubiquinol) .. raw honey fermentation creates identical chemicals as Quinine. Apple Cider Vinegar & Raw Honey, mix together. leave cap loose, otherwise might break cap off. add quality multivitamins & minerals. add some of this concentrate into a gallon of water. manufacturers Ionophore Ions. .. Ionophore Flavonol Ester Lipid Kaempferol Glucoside Quinine Quercetin .. Quinone Ubiquinol Ubiquinone Adrenaline Adrenochrome Quinones https://www.sciencedirect.com/topics/neuroscience/quinones .. i am very uncomfortable with all of this, especially discovering NAD feeds Cancer & Cellular Respiration. i was going perfectly fine for months until this hiccup. in my opinion, we are being deliberately mislead with online data, like i said its going in circles. there is a direct connection between Adrenochrome Phosphorus Quinine or Quinone .. Quinine and chloroquine https://www.sciencedirect.com/science/article/abs/pii/S1357303915003205 Quinine and chloroquine poisoning are characterized by severe cardiovascular toxicity resulting from sodium and potassium channel blockade, leading to hypotension, shock, arrhythmias and cardiac arrest. Arrhythmias are best treated by correction of hypoxia and electrolyte disturbances, and sodium bicarbonate to correct l metabolic acidosis. Hypokalaemia resulting from intracellular potassium transfer is closely related to severity of chloroquine poisoning and should be corrected cautiously. Epinephrine (Adrenaline) is the vasopressor of choice in chloroquine poisoning. .. potassium channel blockade metabolic acidosis beta-blocker toxicity High dose insulin therapy, an evidence based approach to beta blocker/calcium channel blocker toxicity https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985540/ Poison-induced cardiogenic shock (PICS) as a result of beta-blocker (β-blocker) or calcium channel blocker (CCB) overdose. High-dose insulin (HDI) is an emerging therapeutic modality for PICS. .. Epinephrine (Adrenaline) Insulin Hormones Hormonal interactions in carbohydrate metabolism https://pubmed.ncbi.nlm.nih.gov/821893/ .. Quinine and Chloroquine toxicity: hormonal interactions in carbohydrate metabolism beta-blocker channel blockade metabolic acidosis toxicity reversed by: steroid hormones epinephrine insulin The potential detrimental effects of calcium channel blockers’ overdose and current available management https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5787722/ .. interesting side effects, didnt realize this is basically a beta-blocker. why a beta blocker? blood pressure medication? why would blood pressure medication cure malaria? .. Effects of Quinine, Quinidine and Chloroquine on Human Muscle Nicotinic Acetylcholine Receptors https://www.frontiersin.org/articles/10.3389/fphar.2018.01339/full .. https://en.m.wikipedia.org/wiki/Disease-modifying_antirheumatic_drug https://en.m.wikipedia.org/wiki/Chemotaxis https://en.m.wikipedia.org/wiki/Rubiaceae Coffea, the source of coffee, Cinchona, the source of the antimalarial alkaloid quinine. i think the channel‐beta blockers disrupt the eating cycle of mycoplasma protozoa.
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..
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 Smallest Organisms https://en.m.wikipedia.org/wiki/Smallest_organisms Dinitroanilines Microtubule-targeting agents (MTAs), also known as microtubulebinding agents, microtubule-interfering drugs, anti-microtubule drugs, or simply microtubule poisons Microtubule-Targeting Agents: Strategies To Hijack the Cytoskeleton Microtubular cytoskeletons of parasitic protozoa Microtubule-targeting agents and their impact on cancer treatment https://www.sciencedirect.com/science/article/pii/S0171933520300145 https://en.m.wikipedia.org/wiki/Hydrogel_encapsulation_of_quantum_dots .. going threw this old book.. Nutrition and Feeding Strategies in Protozoa Brenda Nisbet found this.. these are aquatic, but it says they are the smallest Microsporidia & make spores. spores make me think much smaller then parent host, small like like exosome mycoplasma or virus, potentially avain or airborn. https://en.m.wikipedia.org/wiki/Microsporidia Microsporidia are a group of spore-forming unicellular parasites. They were once considered protozoans or protists, but are now known to be fungi, or a sister group to fungi. Microsporidia have the smallest known (nuclear) eukaryotic genomes. The parasitic lifestyle of microsporidia has led to a loss of many mitochondrial and Golgi genes, and even their ribosomal RNAs are reduced in size compared with those of most eukaryotes. Currently known microsporidial genomes are 2.5 to 11.6 Mb in size, encoding from 1,848 to 3,266 proteins which is in the same range as many bacteria. (same size as bacteria, might be misidentified as bacteria?) .. https://en.m.wikisource.org/wiki/1911_Encyclopædia_Britannica/Endospora https://scialert.net/fulltextmobile/?doi=ajava.2012.842.850&org=10   Phenanthridine https://en.m.wikipedia.org/wiki/Phenanthridine https://en.m.wikipedia.org/wiki/Nitroimidazole https://en.m.wikipedia.org/wiki/Endopeptidase https://en.m.wikipedia.org/wiki/Pepsin https://en.m.wikipedia.org/wiki/Pepstatin https://en.m.wikipedia.org/wiki/Chlorambucil Hemoglobin proteolytic systems falcipains cysteine proteases ubiquitin proteasomal system (UPS) .. Blocking Plasmodium falciparum development via dual inhibition of hemoglobin degradation and the ubiquitin proteasome system by MG132 https://pubmed.ncbi.nlm.nih.gov/24023882/ Plasmodium falciparum cysteine protease falcipain-2 captures its substrate, hemoglobin https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1166610/ ..  Myxozoa Spore 10 μm https://en.m.wikipedia.org/wiki/Myxozoa https://en.m.wikipedia.org/wiki/Micrometre https://en.m.wikipedia.org/wiki/Nanometre https://en.m.wikipedia.org/wiki/Obligate_parasite https://en.m.wikipedia.org/wiki/Intracellular_parasite https://en.m.wikipedia.org/wiki/Apicomplexa https://en.m.wikipedia.org/wiki/Polistes_atrimandibularis Evasion of host defences A number of obligate intracellular parasites have evolved mechanisms for evading their hosts' cellular defences, including the ability to survive in distinct cellular compartments. One of the mechanisms that hosts employ in their attempt to reduce the replication and spread of pathogens is apoptosis (programmed cell death). Some obligate parasites have developed ways to suppress this phenomenon, for example Toxoplasma gondii although the mechanism is not yet fully understood. .. im looking for something smaller the this. Myxozoa Spore 10 μm similar to Microsporidia with Apicomplexa Toxoplasmosis .. Nanometers (nm) Marine Viruses 40 nm - 400 nm Bacteria 1000 nm Algae 5000 nm Poliovirus 30 nm    https://en.m.wikipedia.org/wiki/Poliovirus .. Genitalium is flask-shaped (about 300 - 600 nm) Pneumoniae is more elongated (about 100 - 1000 nm). Hundreds of mycoplasma species infect animals. Virus range in size from about 20 to 400 nanometres in diameter. Mycoplasma is bigger than Virus. https://cronodon.com/BioTech/bacteria_mycoplasmas.html https://www.microscopemaster.com/mycoplasmas.html .. https://en.m.wikipedia.org/wiki/Mycoplasma https://en.m.wikipedia.org/wiki/Mollicutes .. https://www.microscopemaster.com/mycoplasmas.html     .. https://en.m.wikipedia.org/wiki/Mononegavirales https://en.m.wikipedia.org/wiki/Hendra_virus https://en.m.wikipedia.org/wiki/Henipavirus https://en.m.wikipedia.org/wiki/Hydrozoa https://en.m.wikipedia.org/wiki/Placozoa https://en.m.wikipedia.org/wiki/Cnidaria https://en.m.wikipedia.org/wiki/Polypodium_(animal) https://en.m.wikipedia.org/wiki/Choanozoa The field of embryogenesis uses the word syncytium to refer to the coenocytic blastoderm embryos of invertebrates. https://en.m.wikipedia.org/wiki/Syncytium https://en.m.wikipedia.org/wiki/Blastoderm
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The Big List of Nootropics https://nootropicsexpert.com/nootropics-list/ https://en.m.wikipedia.org/wiki/Phosphatidylcholine https://en.m.wikipedia.org/wiki/Acetylcholine .. Malaria Drugs HCQ & Azith Disease Modifying Antirheumatic Drugs Rheumatic Arthritis https://en.m.wikipedia.org/wiki/Disease-modifying_antirheumatic_drug https://en.m.wikipedia.org/wiki/Azathioprine https://en.m.wikipedia.org/wiki/Azithromycin https://en.m.wikipedia.org/wiki/Rheumatoid_nodule
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