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| 1. | | parent_author | mikewick77 |
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| parent_permlink | protonation-cation-anion |
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| author | mikewick77 |
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| permlink | s746q9 |
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| title | "" |
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| body | "
Thiazol
Fenbendazole
Methylene Blue
Melatonin
Thiamine (B1)
Hydroxychloroquine Sulfate
Thiamine
Fenbendazole
Methylene Blue
Pyrimidine
Thiazole
Thiamine has a 6-Carbon & 5-carbon, smaller then a Benzene.
Thiamine deficiency leads to reduced nitric oxide production
Role of thiamine thiol form in nitric oxide metabolism
Thiamine pyrophosphate a regulator of the nitric oxide
https://youtu.be/O-aQHxp97oA?feature=shared
https://www.eonutrition.co.uk/post/mega-dose-thiamine-beyond-addressing-deficiency
https://www.hormonesmatter.com/thiamine-deficiency-causes-intracellular-potassium-wasting/
https://en.m.wikipedia.org/wiki/Thiaminase
Serotonin Syndrome and Thiamine: Is There a Connection?
https://www.hormonesmatter.com/serotonin-syndrome-thiamine-connection/
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Thiamine plays a key role in intracellular glucose metabolism and it is thought that thiamine inhibits the effect of glucose and insulin on arterial smooth muscle cell proliferation.
Thiamine plays an important role in helping the body convert carbohydrates and fat into energy.
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Prion = Resistant Starch
Thiamine = Carbohydrate Metabolism
Starch = Carbohydrate
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https://en.m.wikipedia.org/wiki/Thiazole
https://en.m.wikipedia.org/wiki/Epothilone
https://en.m.wikipedia.org/wiki/Sorangium_cellulosum
Commercial significant thiazoles include mainly dyes and fungicides. Thifluzamide, Tricyclazole, and Thiabendazole are marketed for control of various agricultural pests. Another widely used thiazole derivative is the non-steroidal anti-inflammatory drug Meloxicam.
The following anthroquinone dyes contain benzothiazole subunits:
Algol Yellow 8, Algol Yellow GC, Indanthren Rubine B, Indanthren Blue CLG, Indanthren Blue CLB.
These thiazole dye are used for dyeing cotton.
The principal mechanism of the epothilone class is the inhibition of the microtubule function. Microtubules are essential to cell division, and epothilones, therefore, stop cells from properly dividing.
Industrial fermentation and genetic manipulation of S. cellulosum is challenging.
Plasmids have been found to not function in S. cellulosum cells. Reproducible genetic alterations must be made directly into the single circular chromosome.
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Indole
Indolamine
Tryptophan
Tryptamine
Hydroxycitrate
Hypochlorous Acid (HOCl)
Glutathione
Potassium
Amide
Amine
Thiamine
Thia = Sulfur
https://en.m.wikipedia.org/wiki/Indolamines
https://en.m.wikipedia.org/wiki/Tryptophan
https://en.m.wikipedia.org/wiki/Tryptamine
https://en.m.wikipedia.org/wiki/Indole
https://en.m.wikipedia.org/wiki/Aminoquinoline
https://en.m.wikipedia.org/wiki/Amide
https://en.m.wikipedia.org/wiki/Amine
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and B1 Thiamine does similar things as Methylene Blue.
B1 Thiamine was originally discovered & synthesized from a dye.
and it seems to help push out sodium from cells, and allow Potassium & Iron Hemoglobin back in.
i think the goal for B1 is to open up blocked mitochondria as an enzyme activator, allowing vitamins & minerals to be most effective, so taken with a good multivitamin is important.
Fenbendazole, Methylene Blue Melatonin.. all the most powerful compounds.. all look like Vitamin B1, or damn near close enough.
i took handfuls of B1 with Vitamin-C, E & Fish oil, specially to focus on my joint collagen.
i was fiddling around with Potassium, Sea Salt & Citric Acid, to get the ions sparked up, but something was missing, thats when i found out B1 puts Potassium inside the cell, where it is supposed to be for PH Buffer Homeostasis.
Potassium was one of the few elements that has direct neutralizing effects on Prion, the other was Brass.
DNA Parasite inside mitochondria, i think its metabolizing the iron, converting Heme into the toxic Oxide, and as a result displacing the Potassium.
making an environment to produce self assembling prion amyloidosis.
i dont want to fiddle too much with Copper & Zinc metals, because a pinch too much is overdose & death.
so it has to be the Potassium, thats how i discovered the chronic deficiency, deposits around infected cells, and how to put it backninto the cells, via B1 as an enzyme activator.
another thing, the literature says most B1 is water soluble & flushed out, requiring an ongoing high level treatments, but if taken with the other vitamins, i think its still doing things, even days after taking them, the Nitrogen & Sulfur is actually like Fenbendazole, meaning it has long lasting effects, possibly weeks of enzyme reactions.
also, Prion actually uses copper in its misfolding process.
[Structural Consequences of Copper Binding to the Prion Protein]
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found two papers comparing Amyloid with Protocell.
Quantitative sensing of microviscosity in protocells and amyloid materials using fluorescence lifetime imaging of molecular rotors
Steps Towards the Formation of A Protocell: The Possible Role of Short Peptides
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Glutathione is a tripeptide (cysteine, glycine, and glutamic acid) found in surprisingly high levels—5 millimolar—concentrations in most cells. This is the same concentration in cells as glucose, potassium, and cholesterol
Amides undergo many chemical reactions, although they are less reactive than esters. Amides hydrolyse in hot alkali as well as in strong acidic conditions. Acidic conditions yield the carboxylic acid and the ammonium ion while basic hydrolysis yield the carboxylate ion and ammonia.
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Resistant Starch
Retrogradation
https://en.m.wikipedia.org/wiki/Resistant_starch
glucose chains can reassociate into short crystalline structures, which typically involves rapid recrystallization of amylose molecules followed by a slow recrystallization of amylopectin molecules in a process called retrogradation.
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Metazoa
Bryozoa
Micrometazoa
Tardigrade
Evolutionary genomics in Metazoa: the mitochondrial DNA as a model system
https://www.sciencedirect.com/science/article/abs/pii/S037811199900270X?via%3Dihub
The rhizome of life: what about metazoa?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3417402/
Thiamine (B1)
Pyrimidine
Thiazole
Thiophene
Thienyl
Thiazolyl
Thiazole
Thiamine
The structure of the infectious prion protein
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7030906/
Oligomeric-Induced Activity by Thienyl Pyrimidine Compounds Traps Prion Infectivity
https://www.jneurosci.org/content/31/42/14882
An Overview of the Synthesis and Antimicrobial, Antiprotozoal, and Antitumor Activity of Thiazole and Bisthiazole Derivatives
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7865802/
Thiazole: A Versatile Standalone Moiety Contributing to the Development of Various Drugs and Biologically Active Agents
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9268695/
Chemical and genetic validation of thiamine utilization as an antimalarial drug target
https://www.nature.com/articles/ncomms3060
Syntheses of Thiophene and Thiazole-Based Building Blocks and Their Utilization in the Syntheses of A-D-A Type Organic Semiconducting Materials with Dithienosilolo Central Unit
https://pubs.acs.org/doi/10.1021/acsomega.2c02195
The importance of thiamine (vitamin B1) in humans
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10568373/
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apparently only Nitrogen, Sulfur, Carbon, Oxygen & Hydrogen are capable og going 5-Carbon, small enough to wrech havoc on nano microbes.
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Self Assembling
Nanoplastics
Nanocrystal
liquid Crystal
Chitin Nanocrystals (CNCs)
Colloidal Particles
Superlattices
The structure and dynamics of chitin nanofibrils in an aqueous environment revealed by molecular dynamics simulations
https://pubs.rsc.org/en/content/articlelanding/2016/ra/c6ra00107f" |
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