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| body | "German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ)
Summary:
The heart derives its energy primarily from fatty acids. However, if a metabolic shift to other energy sources takes place, this can result in congestive heart failure, scientists have now discovered. This underscores the role of metabolism in heart failure. In addition, these findings are relevant for the use of certain anticancer drugs.
Tissue section of a mouse heart: Blood vessels are stained green.
Credit: © Iris Moll, DKFZ
The heart derives its energy primarily from fatty acids. However, if a metabolic shift to other energy sources takes place, this can result in congestive heart failure, scientists from the German Cancer Research Center (DKFZ) and Heidelberg University Hospital have now discovered. This underscores the role of metabolism in heart failure. In addition, these findings are relevant for the use of certain anticancer drugs.
Provided everything goes well, by the time a person turns 75, the heart will have pumped almost 180 million liters of blood through his or her body. To do so, it beats approximately 100,000 times a day, precisely and without any rest, in order to supply the body with oxygen and other vital substances down to its tiniest capillaries. However, up to three million people in Germany have a weary pump: They suffer from cardiac insufficiency, also called congestive heart failure, and hence from symptoms such as shortness of breath, buildup of excess watery fluid, and diminished exercise capacity. Eventually, the condition becomes life-threatening.
"It has been known for a while that congestive heart failure results in a change in metabolism," said Andreas Fischer from the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) in Heidelberg. While healthy hearts produce their energy to more than 75 percent from fatty acids, weak hearts switch to carbohydrates as the preferred energy source. However, this link also works the other way around. In collaboration with other colleagues at the Center and at Heidelberg University Hospital, Fischer has found out that a shift from the metabolism of fatty acids as energy source to carbohydrates causes congestive heart failure.
Fischer's team identified a receptor molecule called Notch-1 as the biochemical key to this effect. The investigators had used a therapeutic antibody that acts primarily in the cells of blood vessel walls to inactivate Notch-1 in mice, thus blocking the downstream signaling pathway. The animals subsequently developed heart failure. In a further experiment, the researchers used a genetic trick and bred mice in whom they could specifically turn off the Notch-1 signaling pathway in endothelial cells, which line the interior surfaces of blood vessels. Again, the animals developed cardiac insufficiency within a few weeks.
"This obvious effect came as a surprise, even to us," said Markus Jabs, who is the first author of the study. But he also has an explanation ready: "For nutrients to travel from the blood vessels into the heart muscle, they must be transported through the endothelial cells." While the transport processes through the blood vessel wall have been studied relatively well, little is known to date about how they are controlled. The DKFZ researchers have now identified the Notch-1 receptor as a key player controlling the transport of fatty acids from the blood into cardiac muscle tissue.
"With Notch-1 inhibited, the heart has less fatty acids available and it must shift to glucose as an energy source," Jabs said. As a result, another signaling pathway called mTOR is activated. This causes the heart muscle to grow, eventually leading to heart failure. In an experiment, blocking this signaling pathway could prevent the development of heart failure in the mice. A diet that was extremely low in carbohydrates had the same effect.
"However, this does not mean that we should completely erase carbohydrates from our meal plan in order to prevent heart failure," said Fischer, who is a physician and a scientist. He is convinced that a diet containing carbohydrates does not alone cause congestive heart failure. "But our results show the immense impact that a change in metabolism, such as in inherited or acquired metabolic disorders, has on the course of congestive heart failure." Thus, the research team may have found an important parameter in the treatment of heart failure.
In addition, the results reported by the DKFZ researchers have far-reaching implications for cancer research. Notch-1 fulfills a wide range of functions in the body and is known to be an oncogene. Mutations that entail its increased activation can lead to the development and growth of tumors.
In theory, this makes the Notch signaling pathway an interesting target for cancer therapy. However, in a number of early clinical trials using an agent that blocks this signaling pathway, participants developed congestive heart failure. "Our results can now explain this seemingly surprising side effect," Fischer said. "These agents should therefore only be used under very close cardiologic control." The scientist also assumes that special diets or additional inhibition of the mTOR signaling pathway during treatment might help prevent the life-threatening side effect of congestive heart failure.
Story Source:
Materials provided by German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ" |
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| body | "Hi, I'm giving away 15 Steem Dollars check my post to find out more
https://steemit.com/giveaway/@stevekelly/massive-giveaway-i-m-celebrating-i-reached-400-followers-in-one-week-get-free-sbd-free-steem-dollars" |
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| body | "Gracias, es un gusto contribuir con la comunidad" |
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| parent_permlink | re-walden-sweetsssj-sixth-day-eleventh-hour-selfvoting-via-a-13-account-content-farm-20180214t042349990z |
|---|
| author | ackza |
|---|
| permlink | re-guiltyparties-re-walden-sweetsssj-sixth-day-eleventh-hour-selfvoting-via-a-13-account-content-farm-20180215t125243349z |
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| title | "" |
|---|
| body | "come on man, sweetsssj is no scammer
dont confuse the fact that oe whale upvoted this into trending for it being true! walden just carefully crafted a lie about her wallet screenshots! By the way thank you for supporting team Ghana, i work with them on discord meetings everyday and its about to get really real man like we will have our own office complex and a few stores of our own and some serious SBD to Fiat local exchange website that will use their local telephone text money system called MTN like they are setup for it to work so easily the students at the local tech univ are working on the local steem/SBD to fiat exchange they see how they can make good money posting developer style posts about stuff like that! Man Steem is gonna be $100 a token this year or at least by 2020
i can see steem at $2000 BECAUSE I believ we CAn be as succeful as Facebook which is a 500 billion dollar marketcap if we got steem there wed get to well 1 bilion marketcap now so 500 times wht steem is now like $4 so thats $2000 yup see thats how i go that number so if steem gets as big as facebook n marketcap , steem will be around $2000, maybe less because they will have created more tokens in a yer or two but if we get thatbig in the next few years or even in 5 to 10 years steem coudl still get to $1000 easily .....
steem at around $10,000 could be real i seriously believe this
Bitcoin shows us that these prices are possible with a 21 million hardcap supply token .... so if we take steem round 300 million tokens soon, and we say steem supply is around 14 times more than bitcoin, and ignoring how much steempower is locked up and not liquid, lets just say if steem had same marketcap as bitcoin the price per steem would be same as bitcoin but divided by 14 so $10,000 bitcoin would be around $714 Steem if Steem marketcap was same as bitcoin ... So if Steem can get to bitcoins nearly 200 billion marketcap we wont hve steem teh same price as bitcoin... but we would still have a good time" |
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| parent_permlink | esteem |
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| author | nadiaa |
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| permlink | energy-and-resources-e70366492f42b |
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| title | "energy and resources" |
|---|
| body | "Earnings are stable and flowing enough. Take care of your health, keep your expenses, and keep your talk. The ebb and flow of the business will drain your energy and resources, you should reduce the risk and delay your investment
" |
|---|
| json_metadata | {"links":[],"image":["https://img.esteem.ws/c7j0x5dv38.jpg"],"tags":["esteem","life","art"],"app":"esteem/1.5.0","format":"markdown+html","community":"esteem"} |
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| weight | 500 |
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| operations | | 0. | | 0. | comment |
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| 1. | | parent_author | "" |
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| parent_permlink | memes |
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| author | kiporen212 |
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| permlink | socialism |
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| title | Socialism |
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| body |  |
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| json_metadata | {"tags":["memes","funny","politics","socialism","libertarian"],"image":["https://steemitimages.com/DQmergyg8e7ojLNvDg69GfgBmsEwSZ2MYAE2PBaMtZ3L3n1/F49D5E17-C439-4A0A-96C8-77494D56B661.jpeg"],"app":"steemit/0.1","format":"markdown"} |
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| permlink | socialism |
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| weight | 10,000 |
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| expiration | 2018-02-15 12:53:39 |
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| operations | | 0. | | 0. | comment |
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| 1. | | parent_author | miguelluis1980 |
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| author | soundterritory |
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| permlink | re-croatia-squad-we-dont-need-no-sleep-20180215t125239 |
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| title | None |
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| body | "Cro mag man" |
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| json_metadata | "" |
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| permlink | a-must-read-for-all-nigerian-steemians |
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| expiration | 2018-02-15 13:02:33 |
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| 1. | | parent_author | "" |
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| parent_permlink | film |
|---|
| author | iqbalshah |
|---|
| permlink | stuntman-film-the-man-from-the-sea |
|---|
| title | "Stuntman Film LAUT (The Man From The Sea)" |
|---|
| body | "@@ -949,17 +949,16 @@
i perfil
-a
man indo
@@ -962,16 +962,69 @@
ndonesia
+ dan ini juga salah satu impian saya di masa sekarang
.%0A%0AKetik
@@ -4401,16 +4401,432 @@
g ini.%0A%0A
+Terimakasih juga kepada aktor/aktris yang sangat ramah terhadap saya dan teman-teman stunt in lainnya, Dean Fujioka, Junko Abe, Taiga, Adipati Dolken, Sekar Sari dan juga saya ucapkan terimakasih kepada tim film dari aceh yang telah mendampingi kami selama proses pengambilan gambar.%0A%0A!%5Bdekju92-20180215-0001.jpg%5D(https://steemitimages.com/DQmRoM9rZNVKmdkrBga27NFSPUvngH54t3U2cUWdoC6bPCJ/dekju92-20180215-0001.jpg)%0A%0A
!%5Biqbaal
" |
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| transaction_id | be036e82fe725926c960608f110c0e342d09ffec |
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| block_num | 19,891,569 |
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| transaction_num | 33 |
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| 34. | | ref_block_num | 34,141 |
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| ref_block_prefix | 1,662,890,756 |
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| expiration | 2018-02-15 13:02:42 |
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| operations | | 0. | | 0. | transfer |
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| 1. | | from | minnowbooster |
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| to | sardar-sani |
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| amount | 0.005 HBD |
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| memo | "You got an upgoat worth roughly 0.8$ in post rewards that will be done by future24. We detected an open value of 0.014 SBD, worth 0.005 SBD in send and refunded that. " |
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| permlink | i-will-find-you-original-art-story-of-final-reuniting-and-a-side-blurb-on-anarchapulco-travel |
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hiveblocks