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| title | "" |
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| body | "
Electron-Donor
Methyl-Donor
Hydrogen-Donor
Nitrogen-Doner
DMSO (Sulfur)
Monounsaturated Oil (Hydrogen)
Niacin (Nitrogen)
Antioxidant
Reducing Agents
Hydrogen Atom Transfer (HAT):
Single Electron Transfer (SET)
..
Oil
[ DMSO ]
[ Castor Oil ]
Carbon Hydrogen
Monounsaturated Oil
Water
[ Niacin ]
[ Honey ]
Carbon Nitrogen
Amino Protein
..
amylin islet amyloid polypeptide (IAPP) autophagy pancreas
MUFA PUFA DMSO sulfur antioxidant solvent oxidation squalene triterpene triterpenoid oleanolic acid
sulfur-based functional groups with unsaturated polymer chains.
Thioesters (Sulfur) formed from coenzyme A, for fatty acid synthesis.
Mono- and bicyclic squalene derivatives as potential proxies for anaerobic photosynthesis in lacustrine sulfur-rich sediments.
The double bonds (unsaturated chains) in squalene provide the basis for its cyclization into various triterpenoid structures.
Squalene: A Triterpene with Unsaturated Chains Synthesized from Acetyl-CoA
Squalene is a naturally occurring, highly unsaturated hydrocarbon that belongs to the class of triterpenes. It is a precursor molecule for the biosynthesis of all animal and plant steroids, including cholesterol.
Biosynthesis: Squalene is synthesized through the mevalonic acid (MVA) pathway or, in some prokaryotes, through the 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway. In eukaryotes, the MVA pathway begins with the condensation of three acetyl-CoA molecules.
Cholesterol synthesis, also known as cholesterologenesis, is a multistep enzymatic process that occurs in the liver's hepatic cells. It starts with acetyl-CoA and takes place in both the cytosol and endoplasmic reticulum (ER) of the hepatocytes. The ER is the primary site of synthesis.
Lacustrine
Lanosterol
Cholesterol
Carotenoid
Hydroxyl & Ketone
Functional Groups
Cyclization: Two farnesyl pyrophosphate molecules combine to form squalene, which is then cyclized to form lanosterol.
Conversion: Lanosterol is converted to cholesterol through a series of steps.
HDL (High-Density Lipoprotein) Cholesterol:
DMSO has been shown to increase levels of apolipoprotein A-I (apoA-I), a key protein component of HDL.This increase in apoA-I is associated with a corresponding increase in secreted HDL.
Sulfur-containing amino acids (SAAs) are potent modulators of lipid metabolism.
SAAs have been shown to increase HDL cholesterol levels.
..
https://en.m.wikipedia.org/wiki/Oleanolic_acid
https://en.m.wikipedia.org/wiki/Organosulfur_chemistry
Terpenoid Synthesis
https://www.sciencedirect.com/topics/chemistry/terpenoid-synthesis
..
Methylene Blue (MB):
Mechanism:
MB acts as a cofactor for the enzyme methemoglobin reductase, which converts methemoglobin back into hemoglobin, allowing it to carry oxygen.
Mainly used for methemoglobinemia, especially in cases of acetaminophen overdose.
Effectiveness:
NAC is generally considered the best treatment for acetaminophen overdose, and it can reduce methemoglobin levels.
NAC is generally considered a safer alternative to MB for individuals with G6PD deficiency.
Elaboration:
Methemoglobin:
When the iron in hemoglobin is oxidized, it becomes methemoglobin, which cannot carry oxygen.
Studies have demonstrated that NAC can significantly reduce DMSO-induced intracellular and mitochondrial reactive oxygen species (ROS) generation.
Solubility in DMSO vs. Other Solvents:
Nicotinic acid is more soluble in DMSO than in water, ethanol, acetone, or diethyl ether.
Highly Soluble:
DMSO is a good solvent for niacin, offering a solubility that is higher than what would be expected based on ideal behavior.
..
getting some good outcomes lately, testing the idea that Castor or Olive oil & DMSO not only make HDL (good) Cholesterol, but converts the bad Cholesterol into good, because of the Antioxidant activity of being an Electron/Hydrogen Donor.
the reason for this is not clearly explained on the internet, but according to the definition of "Antioxidant", DMSO & Castor Oil.
seems to appear to match the requirements, at the smallest atomic level, hydrogen is the main component of oil.
hydrogen is a proton (electron), and HDL cholesterol is synthesized via coenzyme-A (sulfur).
found evidence that DMSO & Castor (any oil) is capable of neutralize & reversing amyloidosis & prion misfolding, specifically because of the powerful antioxidant properties of this Hydrogen Sulfur combination.
i noticed eye floaters after using Fenbendazole, killed parasites living in my eyes, the remains never dissolved.
so the eye dosnt seem to generate the enzymes to break it down, this reminds me of amyloid plaque, in that its exceptionally tough.
DMSO does a lot of different things by itself, but may require the Hydrogen from the oil to work on really tough proteins.
the eye tests are interesting because eyes are natural microscopes, so immediate confirmation its does or does not break things up.
DMSO & Castor may be acting as both an Electron & Hydrogen Donor, making it a very potent antioxidant plus, something else is going on.
trying to get an answer, does DMSO & MSM bind toxic Reactive Nitrogen/Oxygen Species, and restructure them back into antioxidants & amino acids.
ive drank a shot of DMSO at 50/50 raito in both water & oil.
the water does not dilute the almost instant gut punch & bathroom gunpowder blowout.
but with the oil mixed it goes everywhere in the body, almost instantly from head to toe.
DMSO alone appears to strip the oil attributes of Hydrogen, dries everything out, with water its just for topical.
i dont think DMSO alone is key, needs the oil too, otherwise it makes me feel flushed & i think pure DMSO stripes away the body oils, so add it along to make it more neutral to cells.
DMSO Dimethyl sulfoxide, it has the "Methyl" part, but not the 3 Hydrogen Atoms to make "Methyl Doner" (CH3) in the oil, without it it may even accept Hydrogen, essentiality striping the cholesterol & fatty acids required for cellular homeostasis.
too much DMSO & Oil seems to trigger Mass Cell Activation of Histamine &/or Reductive Stress, by the antioxidant activity of taking too much ROS & RNS, requiring Hydrogen Peroxide to neutralize the Sulfur.
..
Antioxidative reductive stress, also known as reductive stress, is a condition where there's an excess of reducing equivalents, like NADH and glutathione, compared to oxidized equivalents, disrupting normal cell processes.
Reductive stress, while seemingly the opposite of oxidative stress, is a state where the cellular environment is too "reduced," leading to imbalances in redox reactions and potentially causing various harmful effects. While oxidative stress is often associated with high levels of reactive oxygen species (ROS) like hydrogen peroxide, reductive stress can also lead to the production of ROS.
Excessive antioxidant activity, prolonged antioxidant signaling, mitochondrial dysfunction, and overactivation of NRF2 pathways can all contribute to reductive stress.
Reductive Stress (RS)
https://en.m.wikipedia.org/wiki/Reductive_stress
Antioxidative Stress
https://en.m.wikipedia.org/wiki/Antioxidative_stress
Reductive stress in cancer: coming out of the shadows
https://www.sciencedirect.com/science/article/abs/pii/S2405803323002133
A dose-dependent effect of dimethyl sulfoxide on lipid content, cell viability and oxidative stress in 3T3-L1 adipocytes
https://pmc.ncbi.nlm.nih.gov/articles/PMC6197677/" |
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| extensions | [] |
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| signatures | | 0. | 1f6cb5f6e9e5dd26e55d84c0f8cf67466a4b2a4ca3b67a3cbbf13e895c69fa3e741356889a21df49d8a205df17232fc1423881eeeb1253c05651782bd0270c6fd0 |
|---|
|
|---|
| transaction_id | c687057e26d14cabd87c9af383829c58a8674e2a |
|---|
| block_num | 96,746,388 |
|---|
| transaction_num | 16 |
|---|
|
|---|
| 17. | | ref_block_num | 15,251 |
|---|
| ref_block_prefix | 3,002,494,130 |
|---|
| expiration | 2025-06-13 13:15:51 |
|---|
| operations | | 0. | | 0. | custom_json |
|---|
| 1. | | required_auths | |
|---|
| required_posting_auths | [] |
|---|
| id | ssc-mainnet-hive |
|---|
| json | {"contractName":"market","contractAction":"cancel","contractPayload":{"type":"buy","id":"46a6b104a87fb765aeea91958522ac1362abd01e"}} |
|---|
|
|---|
|
|---|
|
|---|
| extensions | [] |
|---|
| signatures | | 0. | 204849aab463a9d19d623c5a4c24c3b580319da03f9edc608025b6bce6c53dd96a2f6b992c272f034fc51ea88376116afad762c143744ec7d07f7f43eaf9078363 |
|---|
|
|---|
| transaction_id | e904e22ac1bfb8e073c595ff0e5a3aba6a34df8a |
|---|
| block_num | 96,746,388 |
|---|
| transaction_num | 17 |
|---|
|
|---|
|
|---|
hiveblocks